Reduced serum brain-derived neurotrophic factor in patients with first onset vitiligo

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dc.authorid0000-0003-0000-5568
dc.authorscopusid25932306600
dc.authorscopusid27867662800
dc.authorscopusid29067508300
dc.authorscopusid7102765266
dc.authorscopusid10639223100
dc.authorscopusid55891056300
dc.authorwosidErfan, Gamze/W-8139-2018
dc.authorwosidAlbayrak, Yakup/ABA-7651-2020
dc.contributor.authorYanık, Mehmet Emin
dc.contributor.authorErfan, Gamze
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorAydın, Murat
dc.contributor.authorKulaç, Mustafa
dc.contributor.authorKuloğlu, Murat
dc.date.accessioned2022-05-11T14:10:16Z
dc.date.available2022-05-11T14:10:16Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractPurpose: Vitiligo is an acquired pigmentary skin disease that can cause serious cosmetic problems. There have been numerous and well established studies that have demonstrated the comorbidity of various psychiatric disorders in patients with vitiligo. However, to our knowledge, there have been no studies investigating whether a psychiatric biomarker, such as brain-derived neurotrophic factor (BDNF), is associated with vitiligo. Patients and methods: This study was conducted in Namik Kemal University Medical Faculty, Departments of Dermatology and Psychiatry between January 2013 and September 2014. After meeting inclusion and exclusion criteria, serum BDNF levels were assayed in 57 patients with first onset vitiligo and no known current or past psychiatric disorder and compared with BDNF levels in 58 age and sex matched healthy subjects. Results: The age and female/male ratios were similar between groups. The mean values of serum BDNF were 1.57 +/- 0.97 ng/dL and 2.37 +/- 1.73 ng/dL in the vitiligo group and in the healthy control group, respectively. The mean BDNF level was significantly higher in the healthy control group compared with the vitiligo group (t=2.76, P=0.007). Conclusion: This is the first study to compare serum BDNF levels between patients with vitiligo and healthy subjects. The reduced level of serum BDNF in patients with vitiligo may be directly related to the etiology of vitiligo or associated with the high percentage of psychiatric disorders in that patient population. Further studies are needed to support our preliminary results.
dc.identifier.doi10.2147/NDT.S74826
dc.identifier.endpage2367
dc.identifier.issn1178-2021
dc.identifier.pmid25540586
dc.identifier.scopus2-s2.0-84919414008
dc.identifier.scopusqualityQ2
dc.identifier.startpage2361
dc.identifier.urihttps://doi.org/10.2147/NDT.S74826
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5344
dc.identifier.volume10
dc.identifier.wosWOS:000346259200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYanık, Mehmet Emin
dc.institutionauthorErfan, Gamze
dc.institutionauthorAlbayrak, Yakup
dc.institutionauthorAydın, Murat
dc.institutionauthorKulaç, Mustafa
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofNeuropsychiatric Disease and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectneurotrophin
dc.subjectpsychosomatic
dc.subjectskin
dc.subjectdisease
dc.subjectNerve Growth-Factor
dc.subjectLife Quality Index
dc.subjectAtopic-Dermatitis Patients
dc.subjectKeratinocyte Apoptosis
dc.subjectPsychiatric Morbidity
dc.subjectMajor Depression
dc.subjectHuman Epidermis
dc.subjectMood Disorders
dc.subjectHair Follicle
dc.subjectSubstance-P
dc.titleReduced serum brain-derived neurotrophic factor in patients with first onset vitiligo
dc.typeArticle

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