Impaired vascular function induced by aging: Role of irisin and perivascular adipose tissue

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dc.authorscopusid55919047400
dc.authorscopusid58166943700
dc.authorscopusid55318932400
dc.authorscopusid6603713061
dc.contributor.authorÖzdemir-Kumral, Z.N.
dc.contributor.authorBülbül, Ahmet Murat
dc.contributor.authorÇilingir-Kaya, O.T.
dc.contributor.authorKurtel, H.
dc.date.accessioned2023-05-06T17:23:35Z
dc.date.available2023-05-06T17:23:35Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe aim of the study is to explain the possible effects of exercise-induced novel peptide irisin on endothelial function accompanied by perivascular adipose tissue (PVAT) in aortas of both natural aging and D-galactose (D-Gal) aging mimetic rats. Female Sprague-Dawley rats were randomly divided into 6 groups (n=10/per group): sedentary young group (SY), exercised young group (EY), sedentary aging group (SA), exercised aging group (EA), sedentary D-Gal (300 mg/kg/day, i.p., 9 weeks) induced aging group (S+D-Gal), exercised D-Gal induced aging group (E+D-Gal). Cardiac and aortic samples were collected for biochemical and histopathological examinations. The aortas were taken for contractile response studies in the absence or presence of perivascular adipose tissue (PVAT-/+). The levels of irisin in both plasma and PVAT were detected. Regardless of the models the vaso-relaxant effects of irisin were shown alone and age-related vascular dysfunction has also been recorded compared to the SY group these age-related impaired irisin responses were found to be improved by regular exercise. The plasma and PVAT irisin levels were decreased by aging and exercise reversed this decrement which is verified by the immune expression of irisin in aortic and PVAT tissues. Our results show the differences in vascular function and PVAT in aging and the contribution of PVAT to the response of irisin with exercise in two different aging models. © 2023 Marmara University Press.
dc.description.sponsorshipMarmara Üniversitesi: SAG-C-DRP-130515-0160
dc.description.sponsorshipAcknowledgements: The authors are grateful to histologist Dr. Naziye Ozkan Yenal for her helps in histopathological evolutions. This work was supported by a grant from the Marmara University Research Fund, Istanbul, Turkey, SAG-C-DRP-130515-0160 (received by H.K.).
dc.identifier.doi10.29228/jrp.356
dc.identifier.endpage752
dc.identifier.issn2630-6344
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85151368513
dc.identifier.scopusqualityQ3
dc.identifier.startpage733
dc.identifier.trdizinid1177701
dc.identifier.urihttps://doi.org/10.29228/jrp.356
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12178
dc.identifier.volume27
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBülbül, Ahmet Murat
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectaging
dc.subjectexercise
dc.subjectirisin
dc.subjectPVAT
dc.subjectvascular dysfunction
dc.titleImpaired vascular function induced by aging: Role of irisin and perivascular adipose tissue
dc.typeArticle

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