INVESTIGATION OF THE PROTECTIVE EFFECTS OF POMEGRANATE (Punica granatum L.) PEEL EXTRACT ON LIPOPOLYSACCHARIDE-INDUCED UVEITIS IN RATS

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dc.authoridYayla, Muhammed/0000-0002-0659-3084
dc.authoridHalici, Zekai/0000-0001-6854-6059
dc.authoridUGAN, RUSTEM ANIL/0000-0002-4837-2343
dc.authoridTOKTAY, Erdem/0000-0002-0715-2707
dc.authoridCADIRCI, ELIF/0000-0003-0836-7205
dc.authoridYUKSEL, Tugba Nurcan/0000-0001-5092-1674
dc.contributor.authorYuksel, Tugba Nurcan
dc.contributor.authorYayla, Muhammed
dc.contributor.authorKose, Duygu
dc.contributor.authorUgan, Rustem Anil
dc.contributor.authorToktay, Erdem
dc.contributor.authorAksu Kilicle, Pinar
dc.contributor.authorCadirci, Elif
dc.date.accessioned2024-10-29T17:59:02Z
dc.date.available2024-10-29T17:59:02Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesien_US
dc.description.abstractPomegranate peel contains bioactive ingredients such as flavonoids, ellagitannins, phenolics and proanthocyanidin compounds with high antioxidant activity. Pomegranate peel has antiapoptotic, antioxidant and anti-inflammatory effects due to its high punicalagin content. We aimed to determine the effect of pomegranate peel extract (PPE) on lipopolysaccharide (LPS)-induced uveitis. Sixty rats were seperated randomly into twelve groups (n = 5). The healthy group received intraperitoneal normal saline, the uveitis group received 200 mu g/kg LPS, the dexamethasone (DEX) group received 200 mu g/kg LPS plus 1 mg/kg DEX, the PPE100, PPE300 and PPE500 groups received 200 mu g/kg LPS plus 100, 300 and 500 mg/kg PPE, respectively. The eye tissues were collected at 3rd and 24th hour. and investigated molecularly (Relative quantification of gene expression), biochemically (Superoxide dismutase activity, Glutathione and Malondialdehyde levels) and histopathologically (staining with Harris Hematoxylin and Eosin Y). Tumor Necrosis Factor-alpha, vascular endothelial growth factor, and Caspase-3 levels markedly decreased in a dose-dependent manner in the uveitic rats following PPE administration. PPE administration significantly ameliorated uveitic disorders in oxidative stress factors including Glutathione, Superoxide dismutase and Malondialdehyde, with its effects raising in a dose-dependent manner. PPE eliminated histopathological changes in eye tissues due to uveitis. PPE can be a promising agent by contributing to alternative preventive treatment methods for uveitis with its anti-inflammatory, antioxidative, antiapoptotic and antiangiogenic effects.en_US
dc.description.sponsorshipScientific Research Council of Tekirdag Namik Kemal University TURKIYE [NKUBAP.02.GA.20.240]en_US
dc.description.sponsorshipThe study was supported by the Scientific Research Council of Tekirdag Namik Kemal University TURKIYE with project number NKUBAP.02.GA.20.240.en_US
dc.identifier.doi10.23902/trkjnat.1145462
dc.identifier.endpage20en_US
dc.identifier.issn2528-9691
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85179456409en_US
dc.identifier.startpage11en_US
dc.identifier.trdizinid1164023en_US
dc.identifier.urihttps://doi.org/10.23902/trkjnat.1145462
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1164023
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14601
dc.identifier.volume24en_US
dc.identifier.wosWOS:000981245300003en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTrakya Univ Balkan Yerlesesi Enstituler Binasien_US
dc.relation.ispartofTrakya University Journal of Natural Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAntioxidanten_US
dc.subjectLPS-induced uveitisen_US
dc.subjectPomegranate peelen_US
dc.subjectPunicalaginen_US
dc.subjectTNF-?en_US
dc.titleINVESTIGATION OF THE PROTECTIVE EFFECTS OF POMEGRANATE (Punica granatum L.) PEEL EXTRACT ON LIPOPOLYSACCHARIDE-INDUCED UVEITIS IN RATSen_US
dc.title.alternativeINVESTIGATION OF THE PROTECTIVE EFFECTS OF POMEGRANATE (Punica granatum L.) PEEL EXTRACT ON LIPOPOLYSACCHARIDE-INDUCED UVEITIS IN RATSen_US
dc.typeArticleen_US

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