A Novel Molecule: 1-(2,6 Dichlorobenzyl)-4-(2-(2-4-hydroxybenzylidene)hydrazinyl)pyridinium Chloride and its Interaction with DNA

Basit Öğe Kaydı
dc.authorid0000-0002-0788-8108
dc.authorscopusid55235059200
dc.authorscopusid35293209900
dc.authorscopusid6507417782
dc.authorscopusid35291427500
dc.authorscopusid36612616900
dc.contributor.authorKarasakal, Ayça
dc.contributor.authorParlar, Sulunay
dc.contributor.authorAlptüzün, Vildan
dc.contributor.authorÇetin, Arif E.
dc.contributor.authorTopkaya, Seda Nur
dc.date.accessioned2022-05-11T14:31:05Z
dc.date.available2022-05-11T14:31:05Z
dc.date.issued2021
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractHerein, a novel pyridine derivative, 1-(2,6 dichlorobenzyl)-4-(2-(2-4-hydroxybenzylidene)hydrazinyl)pyridinium chloride (DHPC), was synthesized as a candidate drug molecule. Interaction of DHPC with DNA was used to explore its effect on DNA via Differential Pulse Voltammetry, Cyclic Voltammetry, and Electrochemical Impedance Spectroscopy. We demonstrated that oxidation signal of guanine bases of DNA decreased significantly while that of DHPC increased after its interaction with one another. Our candidate drug molecule exhibits LOD and LOQ, e.g., 1.5 mu g/mL and 4.9 mu g/mL, respectively. Toxicity effect value for DHPC (S%) was calculated as %31, demonstrating the candidate drug molecule's toxic effect on DNA.
dc.description.sponsorshipTekirdag Namik Kemal University [NKUBAP.00]; Izmir Katip Celebi UniversityIzmir Katip Celebi University [:2018-GAP-ECZF-0002]; TUBITAK-BIDEBTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1929B011800172]
dc.description.sponsorshipWe acknowledge partly financial support from Tekirdag Namik Kemal University (Project No:NKUBAP.00.GA.19.217) and Izmir Katip Celebi University (Project No:2018-GAP-ECZF-0002). Ayca Karasakal acknowledges TUBITAK-BIDEB (1929B011800172) for the support during her stay in Izmir Katip Celebi University.
dc.identifier.doi10.1002/elan.202060597
dc.identifier.endpage1825
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85106485222
dc.identifier.scopusqualityQ2
dc.identifier.startpage1819
dc.identifier.urihttps://doi.org/10.1002/elan.202060597
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7311
dc.identifier.volume33
dc.identifier.wosWOS:000654748800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKarasakal, Ayça
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofElectroanalysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDNA
dc.subjectdrug molecule
dc.subjectDNA and drug interaction
dc.subjectpyridinium derivative
dc.subjectelectrochemical biosensor
dc.subjectDerivatives
dc.subjectPyridinium
dc.subjectBiosensors
dc.titleA Novel Molecule: 1-(2,6 Dichlorobenzyl)-4-(2-(2-4-hydroxybenzylidene)hydrazinyl)pyridinium Chloride and its Interaction with DNA
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
7310.pdf
Boyut:
2.12 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Fen Edebiyat Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu