Synthesis, characterization, UV-Vis absorption and cholinesterase inhibition properties of bis-indolyl imine ligand systems

Basit Öğe Kaydı
dc.authorid0000-0002-7347-2223
dc.authorid0000-0001-9386-4892
dc.authorid0000-0002-3579-8062
dc.authorscopusid57201682024
dc.authorscopusid26029066300
dc.authorscopusid34168278000
dc.authorscopusid35866927300
dc.authorscopusid24280865300
dc.authorscopusid55326408200
dc.authorscopusid55308985300
dc.authorwosidk, h/ABA-1339-2020
dc.authorwosidsaglam, mehmet/Y-7456-2019
dc.authorwosidŞenkuytu, Elif/ABI-5315-2020
dc.authorwosidSengul, Ibrahim Fazil/AAG-4368-2019
dc.contributor.authorSağlam, Mehmet Turgut
dc.contributor.authorBingül, Murat
dc.contributor.authorŞenkuytu, Elif
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorZorlu, Yunus
dc.contributor.authorKandemir, Hakan
dc.contributor.authorŞengül, İbrahim Fazıl
dc.date.accessioned2022-05-11T14:31:04Z
dc.date.available2022-05-11T14:31:04Z
dc.date.issued2020
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA number of bis-indolyl imine helical structures has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole with different o-phenyl diamines as pi-spacer bridged. The structures of targeted compounds were identified by FT-IR, mass, H-1 and C-13 NMR spectroscopy along with single crystal X-ray diffraction techniques. The ground state absorption properties of the bis-indolyl compounds were also investigated utilizing UV-Vis absorption spectroscopy. As the biological aspect of the synthesized compounds, the anticholinesterase potency was investigated towards the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. The highest inhibition was determined in the presence of compound 9 with the values of 89.21 and 96.06, better than standard Galantamine, for AChE and BChE, respectively. (C) 2020 Elsevier B.V. All rights reserved.
dc.description.sponsorshipResearch Found of the Gebze Technical University [2019-A-105-37]
dc.description.sponsorshipThis work has been supported by Research Found of the Gebze Technical University (Project Number: 2019-A-105-37). We thank to Dr. Michael Dieter Worle for his support in refining compound 10.
dc.identifier.doi10.1016/j.molstruc.2020.128308
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85083710608
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2020.128308
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7307
dc.identifier.volume1215
dc.identifier.wosWOS:000537220200005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKandemir, Hakan
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIndole
dc.subjectSchiff base
dc.subjectUV-Vis
dc.subjectCholinesterase inhibitor
dc.subjectAcetylcholinesterase Inhibitors
dc.subjectBiological-Activity
dc.subjectBase Derivatives
dc.subjectSchiff-Bases
dc.subjectAntibacterial
dc.subjectComplexes
dc.subjectAnalogs
dc.subjectBis(Indolyl)Methane
dc.subjectChemosensors
dc.subjectAntifungal
dc.titleSynthesis, characterization, UV-Vis absorption and cholinesterase inhibition properties of bis-indolyl imine ligand systems
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
7307.pdf
Boyut:
1.11 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Fen Edebiyat Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu