Protective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis

Basit Öğe Kaydı
dc.authorscopusid7006356462
dc.authorscopusid24436194200
dc.authorscopusid36023238400
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAktaş, Cevat
dc.contributor.authorErboğa, Mustafa
dc.date.accessioned2022-05-11T14:41:26Z
dc.date.available2022-05-11T14:41:26Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study was to investigate the protective effect of quercetin (QE) on oxidative stress, apoptosis, and cell proliferation in the rat testis after streptozotocin (STZ)-induced diabetes. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg). The rats in the QE-treated group were given QE (15 mg/kg) once a day intraperitoneally for 8 weeks starting 3 days prior to STZ injection. At the end of the study, all animals were sacrificed. Testis tissues and blood samples were collected for histopathologic and biochemical analysis. QE treatment significantly decreased the elevated tissue malondialdehyde (MDA) levels and increased the reduced superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) enzyme activities in testis tissues samples. The QE-treated rats in the diabetic group showed an improved histologic appearance and serum testosterone levels. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling (TUNEL) and there was a rise in the expression of proliferating cell nuclear antigen (PCNA) in testis tissues of QE-treated rats in the diabetic group. These results suggest that administration of QE is a potentially beneficial agent to reduce testicular damage in diabetic rats by decreasing oxidative stress. Crown Copyright (c) 2011 Published by Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.fct.2011.11.051
dc.identifier.endpage725
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.issue45385en_US
dc.identifier.pmid22166789
dc.identifier.scopus2-s2.0-84856475646
dc.identifier.scopusqualityQ1
dc.identifier.startpage719
dc.identifier.urihttps://doi.org/10.1016/j.fct.2011.11.051
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9180
dc.identifier.volume50
dc.identifier.wosWOS:000303284600042
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAktaş, Cevat
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectExperimental diabetes
dc.subjectTestis
dc.subjectQuercetin
dc.subjectTUNEL
dc.subjectAntioxidant
dc.subjectTestosteron
dc.subjectCell Nuclear Antigen
dc.subjectInduced Nephrotoxicity
dc.subjectMalondialdehyde Levels
dc.subjectSeminiferous Tubules
dc.subjectSuperoxide-Dismutase
dc.subjectLipid-Peroxidation
dc.subjectTesticular Tissue
dc.subjectFree-Radicals
dc.subjectAntioxidant
dc.subjectFlavonoids
dc.titleProtective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
9180.pdf
Boyut:
1.09 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu