Investigation of the protective effect of erdosteine against cyclosporine-induced injury in rat liver with histological and biochemical methods

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dc.authorid0000-0001-7616-3330
dc.authorscopusid55915615100
dc.authorscopusid55838809000
dc.authorscopusid56047982200
dc.authorscopusid57190797455
dc.authorscopusid23009434800
dc.authorscopusid34875451400
dc.authorscopusid35621697200
dc.authorwosidkaraboga, ihsan/AAZ-9840-2020
dc.contributor.authorNacar, Ahmet
dc.contributor.authorKaraboğa, İhsan
dc.contributor.authorOkuyan, H.M.
dc.contributor.authorKaplan Sefil, Nebihat
dc.contributor.authorNacar, Emel
dc.contributor.authorMotor, Sedat
dc.contributor.authorÖzkan, Orhan Veli
dc.date.accessioned2022-05-11T14:48:32Z
dc.date.available2022-05-11T14:48:32Z
dc.date.issued2015
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Acil Yardım ve Afet Yönetimi Bölümü
dc.description.abstractBackground/aim: In the present study, the protective effect of erdosteine against cyclosporine-induced injury in rat liver was investigated with histological and biochemical methods. Materials and methods: Thirty-two Wistar albino male rats were randomly divided into 4 groups: control (n = 8), cyclosporine (n = 8, 20 mg kg(-1) day(-1) i.p.), cyclosporine + erdosteine (n = 8, erdosteine 12 mg kg(-1) day(-1) orally), and erdosteine (n = 8). At the end of day 12, liver tissues were removed for histological and biochemical analysis. After liver tissues were fixed in 10% buffered neutral formalin, routine histological processes were applied and tissue sections were stained with hematoxylin and eosin, periodic acid-Schiff, and elastic fiber stain methods. One hundred lobules of liver were examined for each group and evaluated statistically. The levels of malondialdehyde and glutathione peroxidase, as well as the activities of superoxide dismutase, were determined. Results: The cyclosporine group showed significant histopathological changes compared to the control. In the cyclosporine + erdosteine group, histopathological changes of hepatic damage were markedly reduced. Histological findings were supported by biochemical results. Conclusion: Erdosteine could attenuate cyclosporine-induced liver injury.
dc.identifier.doi10.3906/sag-1404-6
dc.identifier.endpage1395
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid26775399
dc.identifier.scopus2-s2.0-84947434789
dc.identifier.scopusqualityQ3
dc.identifier.startpage1390
dc.identifier.urihttps://doi.org/10.3906/sag-1404-6
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10655
dc.identifier.volume45
dc.identifier.wosWOS:000365510300031
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaraboğa, İhsan
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCyclosporine
dc.subjecterdosteine
dc.subjectantioxidant system
dc.subjecthepatotoxicity
dc.subjectInduced Oxidative Stress
dc.subjectInduced Hepatotoxicity
dc.subjectMelatonin
dc.subjectExpression
dc.titleInvestigation of the protective effect of erdosteine against cyclosporine-induced injury in rat liver with histological and biochemical methods
dc.typeArticle

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