Delivery of phenolics and caffeic acid phenethyl ester by propolis resin: Chewing gum system

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dc.authorid0000-0003-0437-6139
dc.authorscopusid57215610041
dc.authorscopusid57220210612
dc.authorscopusid6603002455
dc.authorscopusid23979419500
dc.authorscopusid54411196400
dc.authorwosidKolaylı, Sevgi/AFQ-8694-2022
dc.contributor.authorBölük, Esra
dc.contributor.authorAtik, Didem Sözeri
dc.contributor.authorKolaylı, Sevgi
dc.contributor.authorDemirci, Ahmet Şükrü
dc.contributor.authorPalabıyık, İbrahim
dc.date.accessioned2022-05-11T14:45:02Z
dc.date.available2022-05-11T14:45:02Z
dc.date.issued2021
dc.departmentFakülteler, Ziraat Fakültesi, Gıda Mühendisliği Bölümü
dc.description.abstractChewing gums can act as a drug delivery system due to their long duration in the oral cavity. In this study, 26 sugary and sugar-free propolis added chewing gums were produced, and a D-optimal mixture design was used to optimize the amount of components based on the responses (texture, and sensory parameters). It was found that a high amount of propolis (10%) had a negative effect on sensory and textural properties of the samples, however, 5.06% and 4.75% propolis additions can improve the overall acceptance, taste, and odor of PSFC (sugar-free chewing gum) and PSC (sugary chewing gum), respectively. The biological activity of optimized PSC and PSFC were investigated in terms of total phenolic and flavanoid content, antioxidant power, and antibacterial effect against Streptococcus mutans. The results of the present study showed that the 5 min chewed PSC showed a higher inhibition zone on Streptococcus mutans, which was 7.10 mm. The second significant finding was that the total phenolic content, total flavonoid, and antioxidant power of the chewing gum bolus increased after the chewing simulation. Suitable bioactive molecule delivery kinetic model was used for the determination of caffeic acid phenethyl ester (CAPE) releasing, and CAPE was released 80% and 50% in 10 min for PSC and PSFC, respectively. One of the most significant findings in this study was that propolis resin was suitable for chewing gum formulations. Consequently, chewing gum can be a proper delivery product for transporting bioactive components of resin.
dc.description.sponsorshipTuBITAK (The Scientific and Technological Research Council Of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [117O869]
dc.description.sponsorshipThis work was accomplished with the financial support of TuBITAK (The Scientific and Technological Research Council Of Turkey) (Project number: 117O869) .
dc.identifier.doi10.1016/j.fbio.2021.101090
dc.identifier.issn2212-4292
dc.identifier.issn2212-4306
dc.identifier.scopus2-s2.0-85105104453
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2021.101090
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9888
dc.identifier.volume41
dc.identifier.wosWOS:000663351000005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorPalabıyık, İbrahim
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofFood Bioscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPropolis resin
dc.subjectChewing gum
dc.subjectReleasing
dc.subjectKinetic model
dc.subjectStreptococcus mutans
dc.subjectAntioxidant Activity
dc.subjectBrazilian Propolis
dc.subjectSensory Properties
dc.subjectRelease Kinetics
dc.subjectFood Texture
dc.subjectHoney
dc.subjectExtract
dc.subjectQuality
dc.subjectHplc
dc.titleDelivery of phenolics and caffeic acid phenethyl ester by propolis resin: Chewing gum system
dc.typeArticle

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