Is 99mTc-MDP whole body bone scintigraphy adjuvant to 18F-FDG-PET for the detection of skeletal metastases?

Basit Öğe Kaydı
dc.authorscopusid35949526800
dc.authorscopusid6506638114
dc.authorscopusid26026246200
dc.authorscopusid50461202500
dc.contributor.authorŞahin, Ertan
dc.contributor.authorZincirkeser, Sabri
dc.contributor.authorAkcan, Abdullah Barış
dc.contributor.authorElboğa, Umut
dc.date.accessioned2022-05-11T14:40:53Z
dc.date.available2022-05-11T14:40:53Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Ana Bilim Dalı
dc.description.abstractPurpose: Due to the fact that fiuorine-18-fiuorodeoxyglucose positron emission tomography/computed tomography CSF-FDG-PET/CT) and technetium-99m- methylenediphosphonate (99mTc-MDP) whole body scans identify bone metastases by different mechanisms, i.e. by using glucose metabolism and osteoblastic response in the bone, respectively, it can be expected that there may be some differences between these two methods in the number of lesions identified. The aim of this study was to compare the sensitivity,specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) in detecting bone metastases between 18F-FDG-PET/CT and conventional 99mTc-MDP whole body scans. Methods: Between 2006-2009, 121 patients with malignancies (62 male and 59 female, mean age 59.3±10.8 years, range 37-84) were examined with 18F-FDG-PET/CT and conventional 99Tc-MDP whole-body scans for detection of bone metastases. Results: For 18F-FDG-PET/CT and for 99mTC-MDP, sensitivity, specificity, accuracy, PPV and NPV for detecting all studied bone metastases were 88.3, 83.6, 86.7, 91.7, 77.8% and 91.7, 71.0, 84.9, 86.6, 80.8%, respectively. For bone metastases of breast and lung cancers, the specificity and accuracy of PET/CT was higher than that of bone scintigraphy. On the other hand, the sensitivity of bone scintigraphy was higher than PET/CT in breast and lung cancers groups and all patients. In the detection of osteolytic and osteosclerotic metastases no difference was found between the two methods, while for osteolytic lesions the mean standardized uptake value (SUV) max was higher than for osteosclerotic lesions. Conclusion: For the detection of bone metastases the spesificity and accuracy of 18F-FDG-PET/CT were higher compared to bone scintigraphy, while the sensivity was lower. It is the opinion of the authors that both studies are complementary to final diagnosis.
dc.identifier.endpage296
dc.identifier.issn1107-0625
dc.identifier.issue1en_US
dc.identifier.pmid24659678
dc.identifier.scopus2-s2.0-84898867396
dc.identifier.scopusqualityQ3
dc.identifier.startpage291
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8945
dc.identifier.volume19
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahin, Ertan
dc.language.isoen
dc.publisherJournal of B.U.ON.
dc.relation.ispartofJournal of B.U.ON.
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBone metastases
dc.subjectBone scintigraphy
dc.subjectFDG-PET
dc.subjectfluorodeoxyglucose f 18
dc.subjectmedronate technetium tc 99m
dc.subjectadult
dc.subjectaged
dc.subjectarticle
dc.subjectbone atrophy
dc.subjectbone lesion
dc.subjectbone metastasis
dc.subjectbone scintiscanning
dc.subjectbreast cancer
dc.subjectcancer diagnosis
dc.subjectcollimator
dc.subjectcomputer assisted emission tomography
dc.subjectcontrolled study
dc.subjectdiagnostic accuracy
dc.subjectdiagnostic test accuracy study
dc.subjectfemale
dc.subjecthuman
dc.subjectlung cancer
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmultiple myeloma
dc.subjectPET-CT scanner
dc.subjectpredictive value
dc.subjectprostate cancer
dc.subjectretrospective study
dc.subjectsensitivity and specificity
dc.subjectthoracic spine
dc.subjecttumor biopsy
dc.subjectvery elderly
dc.subjectwhole body scintiscanning
dc.subjectAged
dc.subjectBone Neoplasms
dc.subjectFemale
dc.subjectFluorodeoxyglucose F18
dc.subjectHumans
dc.subjectLung Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPositron-Emission Tomography
dc.subjectSensitivity and Specificity
dc.subjectTechnetium Tc 99m Medronate
dc.subjectWhole Body Imaging
dc.titleIs 99mTc-MDP whole body bone scintigraphy adjuvant to 18F-FDG-PET for the detection of skeletal metastases?
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Tıp Fakültesi Koleksiyonu