Is 99mTc-MDP whole body bone scintigraphy adjuvant to 18F-FDG-PET for the detection of skeletal metastases?
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Journal of B.U.ON.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: Due to the fact that fiuorine-18-fiuorodeoxyglucose positron emission tomography/computed tomography CSF-FDG-PET/CT) and technetium-99m- methylenediphosphonate (99mTc-MDP) whole body scans identify bone metastases by different mechanisms, i.e. by using glucose metabolism and osteoblastic response in the bone, respectively, it can be expected that there may be some differences between these two methods in the number of lesions identified. The aim of this study was to compare the sensitivity,specificity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) in detecting bone metastases between 18F-FDG-PET/CT and conventional 99mTc-MDP whole body scans. Methods: Between 2006-2009, 121 patients with malignancies (62 male and 59 female, mean age 59.3±10.8 years, range 37-84) were examined with 18F-FDG-PET/CT and conventional 99Tc-MDP whole-body scans for detection of bone metastases. Results: For 18F-FDG-PET/CT and for 99mTC-MDP, sensitivity, specificity, accuracy, PPV and NPV for detecting all studied bone metastases were 88.3, 83.6, 86.7, 91.7, 77.8% and 91.7, 71.0, 84.9, 86.6, 80.8%, respectively. For bone metastases of breast and lung cancers, the specificity and accuracy of PET/CT was higher than that of bone scintigraphy. On the other hand, the sensitivity of bone scintigraphy was higher than PET/CT in breast and lung cancers groups and all patients. In the detection of osteolytic and osteosclerotic metastases no difference was found between the two methods, while for osteolytic lesions the mean standardized uptake value (SUV) max was higher than for osteosclerotic lesions. Conclusion: For the detection of bone metastases the spesificity and accuracy of 18F-FDG-PET/CT were higher compared to bone scintigraphy, while the sensivity was lower. It is the opinion of the authors that both studies are complementary to final diagnosis.
Açıklama
Anahtar Kelimeler
Bone metastases, Bone scintigraphy, FDG-PET, fluorodeoxyglucose f 18, medronate technetium tc 99m, adult, aged, article, bone atrophy, bone lesion, bone metastasis, bone scintiscanning, breast cancer, cancer diagnosis, collimator, computer assisted emission tomography, controlled study, diagnostic accuracy, diagnostic test accuracy study, female, human, lung cancer, major clinical study, male, multiple myeloma, PET-CT scanner, predictive value, prostate cancer, retrospective study, sensitivity and specificity, thoracic spine, tumor biopsy, very elderly, whole body scintiscanning, Aged, Bone Neoplasms, Female, Fluorodeoxyglucose F18, Humans, Lung Neoplasms, Male, Middle Aged, Positron-Emission Tomography, Sensitivity and Specificity, Technetium Tc 99m Medronate, Whole Body Imaging
Kaynak
Journal of B.U.ON.
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
19
Sayı
1
