In Vitro Fertilization, Levels of Pro-Inflammatory Factors and Lipid Peroxidation

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dc.authorid0000-0001-7432-9915
dc.authorid0000-0001-6415-0874
dc.authorid0000-0001-5992-9488
dc.authorid0000-0002-4060-0583
dc.authorid0000-0002-5605-2980
dc.authorid0000-0002-5630-3399
dc.authorwosidEkmekci, Ozlem/D-4960-2019
dc.authorwosidDonma, Metin/AAB-6079-2020
dc.authorwosidDonma, Orkide/AAI-1853-2019
dc.authorwosidKeser, Zafer/J-4586-2019
dc.authorwosidDonma, Mustafa Metin/ABF-2169-2021
dc.authorwosidEKMEKÇİ, HAKAN/AAC-9833-2021
dc.authorwosidekmekci, hakan/D-4969-2019
dc.contributor.authorYıldızfer, Ferdağ
dc.contributor.authorDonma, Orkide
dc.contributor.authorYen, Mustafa
dc.contributor.authorEkmekci, Özlem
dc.contributor.authorKarataş Kul, Zübeyde Aslı
dc.contributor.authorKeser, Zafer
dc.contributor.authorNalbantoğlu, Burçin
dc.contributor.authorDonma, Mustafa Metin
dc.date.accessioned2022-05-11T14:37:13Z
dc.date.available2022-05-11T14:37:13Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Infertility is a problem concerning 10-15% of the individuals in the fertile period. This study investigated effects of proinflammatory factors as well as lipid hydroperoxides (LPO) levels upon in vitro fertilization (IVF) success. Materials and Methods: In this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (group-1), 26 infertile women before (group-2) and after (group-3) IVF treatment were analyzed. Leptin, leptin receptor, resistin, tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) were analyzed using enzyme-linked immunosorbent assay (ELISA). LPO was determined spectrophotometrically. Mann-Whitney U test, paired samples t test, Wilcoxon signed-rank test as well as Pearson correlation analysis by SPSS were performed for statistical analysis. Results: TNF-alpha, resistin and LPO levels increased (P=0.020, P=0.003, P=0.001, respectively) in group-3 compared to group-2. A significant increase in LPO was noted both in group-2 and -3 compared to controls (P=0.000). LPO were higher in non-pregnants than pregnants in group-2. For pregnants, significant correlations were observed between leptin and resistin in group-2 and TNF-alpha and leptin in group-3. None of these correlations were found for the women, who could not conceive. Conclusion: LPO, leptin-resistin correlation, associations with TNF-alpha may be helpful during the interpretation of IVF success rates.
dc.description.sponsorshipIstanbul University Scientific Research Projects UnitIstanbul University [4319]
dc.description.sponsorshipThis study was financially supported by the Istanbul University Scientific Research Projects Unit (Project No: 4319). There is no conflict of interest in this study.
dc.identifier.endpage284
dc.identifier.issn2008-076X
dc.identifier.issn2008-0778
dc.identifier.issue3en_US
dc.identifier.pmid26644849
dc.identifier.scopus2-s2.0-84946030994
dc.identifier.scopusqualityQ2
dc.identifier.startpage277
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8623
dc.identifier.volume9
dc.identifier.wosWOS:000365932700002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorNalbantoğlu, Burçin
dc.institutionauthorDonma, Mustafa Metin
dc.language.isoen
dc.publisherRoyan Inst
dc.relation.ispartofInternational Journal of Fertility & Sterility
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInfertility
dc.subjectLeptin
dc.subjectResistin
dc.subjectTNF-alpha
dc.subjectLipid Peroxidation
dc.subjectSoluble Leptin Receptor
dc.subjectIvf Success Rates
dc.subjectFollicular-Fluid
dc.subjectAssisted Conception
dc.subjectReactive Protein
dc.subjectOxidative Stress
dc.subjectNitric-Oxide
dc.subjectTnf-Alpha
dc.subjectResistin
dc.subjectSerum
dc.titleIn Vitro Fertilization, Levels of Pro-Inflammatory Factors and Lipid Peroxidation
dc.typeArticle

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