In Vitro Fertilization, Levels of Pro-Inflammatory Factors and Lipid Peroxidation
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Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Royan Inst
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Infertility is a problem concerning 10-15% of the individuals in the fertile period. This study investigated effects of proinflammatory factors as well as lipid hydroperoxides (LPO) levels upon in vitro fertilization (IVF) success. Materials and Methods: In this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (group-1), 26 infertile women before (group-2) and after (group-3) IVF treatment were analyzed. Leptin, leptin receptor, resistin, tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) were analyzed using enzyme-linked immunosorbent assay (ELISA). LPO was determined spectrophotometrically. Mann-Whitney U test, paired samples t test, Wilcoxon signed-rank test as well as Pearson correlation analysis by SPSS were performed for statistical analysis. Results: TNF-alpha, resistin and LPO levels increased (P=0.020, P=0.003, P=0.001, respectively) in group-3 compared to group-2. A significant increase in LPO was noted both in group-2 and -3 compared to controls (P=0.000). LPO were higher in non-pregnants than pregnants in group-2. For pregnants, significant correlations were observed between leptin and resistin in group-2 and TNF-alpha and leptin in group-3. None of these correlations were found for the women, who could not conceive. Conclusion: LPO, leptin-resistin correlation, associations with TNF-alpha may be helpful during the interpretation of IVF success rates.
Açıklama
Anahtar Kelimeler
Infertility, Leptin, Resistin, TNF-alpha, Lipid Peroxidation, Soluble Leptin Receptor, Ivf Success Rates, Follicular-Fluid, Assisted Conception, Reactive Protein, Oxidative Stress, Nitric-Oxide, Tnf-Alpha, Resistin, Serum
Kaynak
International Journal of Fertility & Sterility
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
9
Sayı
3
