Association of ACP1 genotypes and clinical parameters in patients with metabolic syndrome

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dc.authorid0000-0002-1100-765X
dc.authorid0000-0002-1100-765X
dc.authorid0000-0002-6044-1372
dc.authorwosidAkkiprik, Mustafa/A-6453-2017
dc.authorwosidAkkiprik, Mustafa/AAD-6167-2020
dc.contributor.authorAkkiprik, Mustafa
dc.contributor.authorÖzdemir Sertoğlu, Filiz
dc.contributor.authorÇaglayan, Sinan
dc.contributor.authorAral, Cenk
dc.contributor.authorÖzışık, Gökhan
dc.contributor.authorAtabey, Zebra
dc.contributor.authorÖzer, Sıdıka Ayşe
dc.date.accessioned2022-05-11T14:28:25Z
dc.date.available2022-05-11T14:28:25Z
dc.date.issued2011
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractAim: Acid phosphatase locus 1 (ACP1) encodes a polymorphic enzyme and has potential implications for the development of metabolic syndrome (MS) by altering insulin sensitivity. The aim of this study was to determine whether a relationship exists between ACP1 genotypes and various metabolic syndrome risk factors. Materials and methods: We employed a PCR-RFLP based genotyping of ACP1 in a cohort of 70 patients with MS and 168 healthy individuals. Results: When compared to controls, genotypes associated with low enzyme activity were observed at significantly lower frequencies in both sexes. Of note, high enzyme activity genotypes were more common in patients with MS when compared with medium and low enzyme activity genotypes. *A allele frequency was not different between patients and controls even considering sex; however, there was a good correlation of the presence of the allele with body composition, serum cortisol levels and suppressibility of cortisol, particularly in women with MS. Conclusion: Our findings suggest that low enzyme activity genotypes seem to be associated with a protective effect for the development of MS. Additionally, *A allele carriage affects body composition in women but not in men, and the presence of this allele might modulate serum cortisol levels as well as its suppressibility in both sexes, in an inverse manner.
dc.description.sponsorshipTurkish Diabetes Foundation; Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [SBAG-K-104S272]
dc.description.sponsorshipThis study was supported in part by grants from the Turkish Diabetes Foundation and from the Scientific and Technological Research Council of Turkey (TUBITAK) (SBAG-K-104S272) to SC.
dc.identifier.doi10.3906/sag-0910-362
dc.identifier.endpage541
dc.identifier.issn1300-0144
dc.identifier.issue3en_US
dc.identifier.startpage533
dc.identifier.urihttps://doi.org/10.3906/sag-0910-362
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6822
dc.identifier.volume41
dc.identifier.wosWOS:000291669500022
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAral, Cenk
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMetabolic syndrome
dc.subjectACP1 genotype
dc.subjectclinical variables
dc.subjectcortisol
dc.subjectCell Acid-Phosphatase
dc.subjectProtein-Tyrosine-Phosphatase
dc.subjectGene
dc.subjectPolymorphism
dc.subjectCholesterol
dc.subjectExpression
dc.subjectCortisol
dc.titleAssociation of ACP1 genotypes and clinical parameters in patients with metabolic syndrome
dc.typeArticle

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