Epidemiology, Clinical and Microbiological Characteristics of Invasive Streptococcal Infections in Turkey, 2010-2011

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dc.authorid0000-0003-1115-0429
dc.authorid0000-0002-3128-0581
dc.authorwosidAYDIN, FARUK/AAL-6973-2021
dc.authorwosidAkyar, Isin/D-7950-2017
dc.authorwosidakyar, ışın/D-3362-2015
dc.contributor.authorTopkaya, Aynur Eren
dc.contributor.authorBalıkçı, Ahmet
dc.contributor.authorAydın, Faruk
dc.contributor.authorHasçelik, Ayşe Gülşen
dc.contributor.authorKayman, Tuba
dc.contributor.authorKeşli, Recep
dc.contributor.authorBayraktar, Banu
dc.date.accessioned2022-05-11T14:42:10Z
dc.date.available2022-05-11T14:42:10Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractA one-year active surveillance study was conducted to investigate the epidemiological and microbiological characteristics of invasive group A streptococci (GAS) infections in Turkey and to provide data for the establishment of national preventive strategies related to invasive GAS infections. A total of 46 clinical microbiology laboratories from 12 different regions of Turkey (Istanbul; Eastern and Western Marmara; Eastern and Western Blacksea; Aegean; Mediterranean; Western, Central, Northeastern, Middle-eastern and Southeastern Anatolia) participated in the study. Accordingly, GAS strains isolated from sterile body sites (blood, cerebrospinal, synovial, pleural, peritoneal, pericardial fluids) in the study centers between June 2010-June 2011, were sent to Maltepe University Hospital Clinical Microbiology Laboratory for microbiological confirmation and further analysis. The isolates were identified by conventional methods, and for serotyping, opacity factor (OF) and T protein types were investigated. For genotyping GAS lysate preparation, emm gene amplification and sequencing were performed by using the protocols recommended by Centers for Disease Control and Prevention. A total of 65 invasive GAS strains were isolated in 15 of the participant centers, during the study period. The rate of invasive GAS isolation exhibited regional variation, with the highest rates in the Eastern Blacksea (Trabzon, n=19), followed by Istanbul (n=17) and Western Anatolia (Ankara, Konya, n=14). Of the patients with invasive GAS infection 33 were female, 32 were male, with the age range of 0-89 years. GAS strains were most commonly isolated from soft tissue specimens (n=18), followed by abscess material (n=10), sterile body fluids (n=8) and blood (n=7) samples. Serotyping revealed that 55% (36/65) of the strains were OF positive, and the majority of T protein was polygroup T (n=20), followed by U (n=14), B (n=5), X (n=3) and Y (n=2). T protein was not detected in 22 isolates. The strains were found to have 17 different emm types; emm1 (n=13), emm4 (n=6), emm6 (n=6), emm12 (n=6), emm24 (n=4), emm14 (n=3) and emm28 (n=3). Nine of the strains could not be typed by sequencing. The correlation between emm typing and serotyping was detected as 58%. It was observed that 26-valent vaccines included 70.5% of the invasive GAS strains included in this study. Our study provided initial data concerning the epidemiological properties of invasive GAS infections and characterization of GAS strains in Turkey. The incidence of invasive GAS infections is low in our country. Although immunization programme by 26-valent GAS vaccine is not currently an urgent public health issue for our country, the results of this study indicated that emm types 4 and 24 should better be included in such a vaccine to be used in Turkey. Additionally, since epidemiological features of GAS infections and the microbiological characteristics of the strains can vary by time, for the diagnosis of invasive streptococcal infections and to take the necessary preventive measures, epidemiological studies should be conducted repeatedly.
dc.identifier.endpage13
dc.identifier.issn0374-9096
dc.identifier.issue1en_US
dc.identifier.pmid24506711
dc.identifier.scopus2-s2.0-84897629912
dc.identifier.scopusqualityQ4
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9263
dc.identifier.volume48
dc.identifier.wosWOS:000332131600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTopkaya, Aynur Eren
dc.language.isotr
dc.publisherAnkara Microbiology Soc
dc.relation.ispartofMikrobiyoloji Bulteni
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGroup A streptococci
dc.subjectinvasive infection
dc.subjectepidemiology
dc.subjectemm gene
dc.subjectsequencing
dc.subjectserotyping
dc.subjectGroup-A Streptococci
dc.subjectUnited-States
dc.subjectPyogenes
dc.subjectDisease
dc.subjectOntario
dc.subjectVaccine
dc.titleEpidemiology, Clinical and Microbiological Characteristics of Invasive Streptococcal Infections in Turkey, 2010-2011
dc.typeArticle

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