Do we really need to coat the novel silicone intranasal splints with antibiotics?
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: The novel silicone intranasal splints are suggested to resist biofilm formation due to their surface characteristics. We aimed to ascertain the necessity of coating these splints with antibiotics to prevent splint associated infections, in vitro. Materials and methods: Pieces of Doyle II airway nasal splints made of medical grade silicone were divided into two test groups, treated with either (i) 0.2% nitrofurazone solution or (ii) 0.2% nitrofurazone containing ointment, and a control group, treated with (iii) 0.9% saline. Splint pieces were then incubated with Staphylococcus aureus solutions at 37 degrees C for 48 and 96 h. Following this, the splint pieces were incubated in 20 ml Mueller Hinton agar and appearing colonies were counted. Results: Following 48 and 96 h of incubation, the colonization rates in the saline group were significantly higher than the nitrofurazone ointment group (p < 0.001). The colonization rates in the liquid nitrofurazone group were significantly lower in comparison to the nitrofurazone ointment group (p < 0.001 and p = 0.019 respectively). Conclusions: The method of coating the splints with antibiotic was superior to using uncoated splints in terms of preventing S. aureus colonization. The rather smooth surfaces of the splints were insufficient to block bacterial colonization and coating them with antibiotics seems to be beneficial for the prevention of infections. (C) 2016 Elsevier Inc. All rights reserved.
Açıklama
24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) -- MAY 10-13, 2014 -- Barcelona, SPAIN
Anahtar Kelimeler
Toxic-Shock-Syndrome, Nasal Splints, Bacterial-Colonization, Septal Splints, Surgery, Decolonization, Prevalence, Morbidity, Adhesion, Efficacy
Kaynak
American Journal of Otolaryngology
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
37
Sayı
5
