Bistability Analysis of an Apoptosis Model in the Presence of Nitric Oxide

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dc.authorid0000-0001-5920-0400
dc.authorscopusid54279389500
dc.authorscopusid8754351000
dc.authorscopusid6604017391
dc.authorwosidBağcı, Elife Zerrin/A-9660-2016
dc.authorwosidbagci, elife/B-9032-2012
dc.contributor.authorŞen, S. Murat
dc.contributor.authorBağcı, Elife Zerrin
dc.contributor.authorÇamurdan, Mehmet C.
dc.date.accessioned2022-05-11T14:28:26Z
dc.date.available2022-05-11T14:28:26Z
dc.date.issued2011
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractBistability in apoptosis, or programmed cell death, is crucial for the healthy functioning of multicellular organisms. The aim in this study is to show the presence of bistability in a mitochondria-dependent apoptosis model under nitric oxide effects using chemical reaction network theory. The model equations are a set of coupled ordinary differential equations arising from the assumed mass action kinetics. Whether these equations have a capacity for bistability (cell survival and apoptosis) is determined using a modular approach in which the model is decomposed into modules. Each module contains only a subset of the whole model and is analyzed separately. It is seen that bistability in a module is preserved throughout the whole model after adding the remaining reactions in the pathway on these modules. It is also found that inhibitor effect of some proteins and the appearance of a reacting protein in a later stage as a product is a desired feature but not sufficient for bistability (in the absence of cooperativity effects). On the whole model, two apoptotic and two cell survival states are obtained depending on the initial cell conditions. The results suggest that the antiapoptotic effects of nitric oxide species are responsible for the bistable character of the apoptotic pathway when cooperativity is not assumed in the apoptosome formation.
dc.identifier.doi10.1007/s11538-010-9613-5
dc.identifier.endpage1968
dc.identifier.issn0092-8240
dc.identifier.issn1522-9602
dc.identifier.issue8en_US
dc.identifier.pmid21191663
dc.identifier.scopus2-s2.0-79959597438
dc.identifier.scopusqualityQ1
dc.identifier.startpage1952
dc.identifier.urihttps://doi.org/10.1007/s11538-010-9613-5
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6823
dc.identifier.volume73
dc.identifier.wosWOS:000292160300012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBağcı, Elife Zerrin
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofBulletin of Mathematical Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectBistability
dc.subjectChemical reaction network theory
dc.subjectMathematical-Model
dc.subjectReaction Networks
dc.subjectComplex
dc.subjectProcaspase-9
dc.subjectInjectivity
dc.subjectActivation
dc.titleBistability Analysis of an Apoptosis Model in the Presence of Nitric Oxide
dc.typeArticle

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