Lipoprotein-associated phospholipase A2 levels are associated with erectile dysfunction in patients without known coronary artery disease

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dc.authorid0000-0002-7459-584X
dc.authorid0000-0002-0690-2529
dc.authorid0000-0001-9115-7203
dc.authorid0000-0002-0553-3012
dc.authorscopusid25026476400
dc.authorscopusid56023692600
dc.authorscopusid24492292800
dc.authorscopusid6603965905
dc.authorscopusid35757662200
dc.authorscopusid8514414100
dc.authorscopusid35768988000
dc.authorwosidBesiroglu, Huseyin/AAM-5318-2020
dc.authorwosidinal, ali/J-8056-2012
dc.authorwosiddursun, murat/C-6318-2019
dc.contributor.authorOtunçtemur, Alper
dc.contributor.authorŞahin, S.
dc.contributor.authorÖzbek, Emin
dc.contributor.authorCekmen, M.
dc.contributor.authorİnal, A.
dc.contributor.authorTülübaş, Feti
dc.contributor.authorKöklü, I.
dc.date.accessioned2022-05-11T14:42:05Z
dc.date.available2022-05-11T14:42:05Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractEndothelial dysfunction and microvascular damage play a crucial role in the pathogenesis of erectile dysfunction (ED). Lp-PLA2 is a calcium-independent member of the phospholipase A2 family and hydrolyses oxidised phospholipids on low-density lipoprotein (LDL) particles that plays a pivotal role in ox-LDL-induced endothelial dysfunction. The purpose of the current study was to determine the association between Lp-PLA2 levels and ED in patients without known coronary artery disease (CAD). All patients were evaluated for ED and divided into two groups: 88 patients suffering from ED for >1year were enrolled as an experimental group and 88 patients without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. Levels of Lp-PLA2 were measured in serum by colorimetric assay. The relationship between Lp-PLA2 levels and ED in patients was evaluated statistically. The mean age of patients with ED group was 59.4 +/- 11.32 and 55.8 +/- 9.67 in the control group. Plasma Lp-PLA2 levels were significantly higher in ED than in the control group (220.3 +/- 66.90 and 174.8 +/- 58.83pgml(-1), respectively, P<0.001). The Lp-PLA2 levels were negatively correlated with score of ED (r=-0.482, P<0.05). In logistic regression analysis, enhanced plasma Lp-PLA2 levels result in approximately 1.2-fold increase in ED [1.22 (1.25-2.76)]. In this study, serum Lp-PLA2 levels were found to be associated with endothelial dysfunction predictive of ED. Serum Lp-PLA2 level appears to be a specific predictor of ED, and it may be used in early prediction of ED in the male population.
dc.identifier.doi10.1111/and.12322
dc.identifier.endpage710
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue6en_US
dc.identifier.pmid25091174
dc.identifier.scopus2-s2.0-84935039979
dc.identifier.scopusqualityQ2
dc.identifier.startpage706
dc.identifier.urihttps://doi.org/10.1111/and.12322
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9213
dc.identifier.volume47
dc.identifier.wosWOS:000357431400015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTülübaş, Feti
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEndothelial dysfunction
dc.subjecterectile dysfunction
dc.subjectIIEF-5
dc.subjectlipoprotein-associated phospholipase A2
dc.subjectAsymmetric Dimethylarginine Level
dc.subjectCardiovascular Risk-Factors
dc.subjectNitric-Oxide Production
dc.subjectEndothelial-Cells
dc.subjectNadph Oxidase
dc.subjectA(2) Lp-Pla(2)
dc.subjectLysophosphatidylcholine
dc.subjectMen
dc.subjectPathway
dc.subjectHealth
dc.titleLipoprotein-associated phospholipase A2 levels are associated with erectile dysfunction in patients without known coronary artery disease
dc.typeArticle

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