Lipoprotein-associated phospholipase A2 levels are associated with erectile dysfunction in patients without known coronary artery disease
Loading...
Files
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-Blackwell
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Endothelial dysfunction and microvascular damage play a crucial role in the pathogenesis of erectile dysfunction (ED). Lp-PLA2 is a calcium-independent member of the phospholipase A2 family and hydrolyses oxidised phospholipids on low-density lipoprotein (LDL) particles that plays a pivotal role in ox-LDL-induced endothelial dysfunction. The purpose of the current study was to determine the association between Lp-PLA2 levels and ED in patients without known coronary artery disease (CAD). All patients were evaluated for ED and divided into two groups: 88 patients suffering from ED for >1year were enrolled as an experimental group and 88 patients without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. Levels of Lp-PLA2 were measured in serum by colorimetric assay. The relationship between Lp-PLA2 levels and ED in patients was evaluated statistically. The mean age of patients with ED group was 59.4 +/- 11.32 and 55.8 +/- 9.67 in the control group. Plasma Lp-PLA2 levels were significantly higher in ED than in the control group (220.3 +/- 66.90 and 174.8 +/- 58.83pgml(-1), respectively, P<0.001). The Lp-PLA2 levels were negatively correlated with score of ED (r=-0.482, P<0.05). In logistic regression analysis, enhanced plasma Lp-PLA2 levels result in approximately 1.2-fold increase in ED [1.22 (1.25-2.76)]. In this study, serum Lp-PLA2 levels were found to be associated with endothelial dysfunction predictive of ED. Serum Lp-PLA2 level appears to be a specific predictor of ED, and it may be used in early prediction of ED in the male population.
Description
Keywords
Endothelial dysfunction, erectile dysfunction, IIEF-5, lipoprotein-associated phospholipase A2, Asymmetric Dimethylarginine Level, Cardiovascular Risk-Factors, Nitric-Oxide Production, Endothelial-Cells, Nadph Oxidase, A(2) Lp-Pla(2), Lysophosphatidylcholine, Men, Pathway, Health
Journal or Series
Andrologia
WoS Q Value
Q3
Scopus Q Value
Q2
Volume
47
Issue
6
