Relationship among MIF, MCP-1, viral loads, and HBs Ag levels in chronic hepatitis B patients

Basit Öğe Kaydı
dc.authorscopusid36867089200
dc.authorscopusid36608599700
dc.authorscopusid7102765266
dc.authorscopusid37058172000
dc.authorscopusid55881189500
dc.authorscopusid57196589837
dc.authorscopusid55445082300
dc.authorwosidYildirim, Oguzhan/ABI-8174-2020
dc.contributor.authorGüneş, Hayati
dc.contributor.authorMete, Rafet
dc.contributor.authorAydın, Murat
dc.contributor.authorTopçu, Birol
dc.contributor.authorOran, Mustafa
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:07:34Z
dc.date.available2022-05-11T14:07:34Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground/aim: To determine whether macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1) levels in patients with hepatitis B (HB) are different than in normal individuals and whether the HB surface antigen (HBs Ag) level and viral load are correlated with each other and with the two aforementioned parameters. Materials and methods: Sera were obtained from 52 chronic active HB (CAHB) patients and 33 healthy controls, and their MIF and MCP-1 levels were measured. Statistical analyses were performed. A value of P < 0.05 was considered statistically significant. Results: The MIF and MCP-1 values of the control group were increased compared to those of the CAHB group. The MIF and MCP-1 levels were negatively correlated with HBs Ag levels and viral loads. The MIF and MCP-1 levels were positively correlated. The HBs Ag levels and the log10 of the viral loads were positively correlated. Conclusion: We conclude that the negative correlation of MIF and MCP-1 with viral load and HBs Ag levels may be due to T-cell deficiency, antinuclear antibody seropositivity, and/or inhibition of chemokine ligand 2 receptors by viral antigens. More studies with a greater number of subjects are needed to evaluate the potential role of MIF and MCP in CAHB.
dc.identifier.doi10.3906/sag-1401-171
dc.identifier.endpage637
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid26281331
dc.identifier.scopus2-s2.0-84929747998
dc.identifier.scopusqualityQ3
dc.identifier.startpage634
dc.identifier.urihttps://doi.org/10.3906/sag-1401-171
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5147
dc.identifier.volume45
dc.identifier.wosWOS:000356357800024
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüneş, Hayati
dc.institutionauthorMete, Rafet
dc.institutionauthorAydın, Murat
dc.institutionauthorTopçu, Birol
dc.institutionauthorOran, Mustafa
dc.institutionauthorDoğan, Mustafa
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic active hepatitis B
dc.subjectmacrophage migration inhibitory factor
dc.subjectmonocyte chemoattractant protein-1
dc.subjectviral load
dc.subjectHBs Ag
dc.subjectMigration Inhibitory Factor
dc.subjectMonocyte Chemoattractant Protein-1
dc.subjectHypertonic Saline
dc.subjectImmune-Response
dc.subjectPlasma-Levels
dc.subjectChemokines
dc.subjectInfection
dc.subjectAssociation
dc.subjectProtection
dc.subjectCorrelate
dc.titleRelationship among MIF, MCP-1, viral loads, and HBs Ag levels in chronic hepatitis B patients
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
5147.pdf
Boyut:
100.7 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu