Are the leading drugs against Staphylococcus aureus reallytoxic to cartilage?

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dc.authorid0000-0003-2003-6337
dc.authorid0000-0003-2112-4056
dc.authorid0000-0001-9052-4411
dc.authorscopusid57196589837
dc.authorscopusid56258081800
dc.authorscopusid35197435300
dc.authorscopusid56715752200
dc.authorscopusid56769801000
dc.authorscopusid23102238400
dc.authorscopusid56002899200
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.authorwosidMahirogullari, Mahir/AAA-4742-2020
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.authorwosidsirin, duygu yasar/AAR-8685-2020
dc.authorwosidISYAR, Mehmet/O-9019-2016
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorİşyar, Mehmet
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorBilir, Bülent
dc.contributor.authorŞirin, Duygu Yaşar
dc.contributor.authorÇakmak, Selami
dc.contributor.authorMahiroğulları, Mahir
dc.date.accessioned2022-05-11T14:09:58Z
dc.date.available2022-05-11T14:09:58Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.descriptionMiddle East Respiratory Syndrome Coronavirus (MERS-CoV) Research Initiative Workshop -- SEP 09-10, 2015 -- Riyadh, SAUDI ARABIA
dc.description.abstractMany studies have shown that the toxic effects of local antibiotics on bone and cartilage limit orthopedic surgeons. In this study, we evaluated three antibacterial agents used locally to treat highly mortal and morbid diseases in the field of orthopedics, such as septic arthritis. Are vancomycin, teicoplanin, and linezolid, which are archenemies of Staphylococcus aureus, really toxic to chondrocytes? The purpose of the study was to investigate the effects of antibiotics, which are used against S. aureus, on human chondrocytes in vitro. Primary cell cultures obtained from gonarthrosis patients were divided into two main groups. One of these groups was designated as the control chondrocyte culture. The other group was divided into three subgroups, and each group was exposedto vancomycin, teicoplanin, or linezolid. Cell culture samples were characterized by immunophenotyping following incubation with the three different antibiotics. Before and after the agents were administered, the cultures were subjected to inverted and environmental scanning electron microscopy. The number of live cells and the proliferation rate were monitored with the MTT-assay. We found that vancomycin, teicoplanin, and linezolid do not have chondrotoxic effects. Vancomycin, teicoplanin, and linezolid had no chondrotoxic activity during in vitro culture, which supports the argument that these agents can safely be used in orthopedic surgery, especially against methicillin-resistant S. aureus agents. (C) 2015 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Limited. All rights reserved.
dc.identifier.doi10.1016/j.jiph.2015.10.004
dc.identifier.endpage258
dc.identifier.issn1876-0341
dc.identifier.issn1876-035X
dc.identifier.issue3en_US
dc.identifier.pmid26603270
dc.identifier.scopus2-s2.0-84947309467
dc.identifier.scopusqualityQ1
dc.identifier.startpage251
dc.identifier.urihttps://doi.org/10.1016/j.jiph.2015.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5229
dc.identifier.volume9
dc.identifier.wosWOS:000376463900010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDoğan, Mustafa
dc.institutionauthorBilir, Bülent
dc.institutionauthorŞirin, Duygu Yaşar
dc.language.isoen
dc.publisherElsevier Science London
dc.relation.ispartofJournal of Infection and Public Health
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChondrocyte
dc.subjectLinezolid
dc.subjectTeicoplanin
dc.subjectToxicity
dc.subjectVancomycin
dc.subjectLoaded Bone-Cement
dc.subjectArticular-Cartilage
dc.subjectAntibiotic Delivery
dc.subjectHuman Chondrocytes
dc.subjectCytotoxicity
dc.subjectInjection
dc.subjectInfection
dc.subjectDecrease
dc.subjectGrowth
dc.subjectModel
dc.titleAre the leading drugs against Staphylococcus aureus reallytoxic to cartilage?
dc.typeConference Object

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