The effects of Eicosapentaenoic acid on the endothelium of the carotid artery of rabbits on a high-cholesterol diet

Basit Öğe Kaydı
dc.authorid0000-0002-1801-2021
dc.authorid0000-0002-6516-6285
dc.authorid0000-0003-2465-5389
dc.authorscopusid35486863400
dc.authorscopusid12645794600
dc.authorscopusid6508378888
dc.authorscopusid57204598049
dc.authorscopusid6602245602
dc.authorscopusid12752602200
dc.authorscopusid7004337877
dc.authorwosidSati, Leyla/C-2489-2016
dc.authorwosidCayli, Sevil/V-2342-2019
dc.contributor.authorÇaylı, Sevil
dc.contributor.authorSati, Leyla
dc.contributor.authorSeval Çelik, Yasemin
dc.contributor.authorTuncer, M. Altug
dc.contributor.authorYaymaci, Bengi
dc.contributor.authorBerkman, Zafer
dc.contributor.authorDemir, Ramazan
dc.date.accessioned2022-05-11T14:34:46Z
dc.date.available2022-05-11T14:34:46Z
dc.date.issued2010
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.description.abstractThe preventive and therapeutic effects of Eicosapentaenoic acid (EPA) on diet-induced hyperlipidemia in rabbits have been investigated. Eighteen New Zealand rabbits were randomly divided into three groups of 6 subjects each; experimental group-I (EG-I) was administered a cholesterol rich diet, experimental group-II (EG-II) was treated with EPA (300 mg/kg/d) following a cholesterol-rich diet and the control group (CG) had a standard diet. Blood samples were collected at day 0 and at the 4th and 12th weeks of EG-II to obtain serum levels of total cholesterol (TC), high density lipid-cholesterol (HDL-C), low density lipid-cholesterol (LDL-C) and triglyceride (TG). From each group tissue samples were collected from the carotid artery for immunohistochemistry and electron microscopy. Our results showed that EPA could significantly lower (p<0.001) serum TC, LDL-C, HDLC and TG levels with a reduction of 35%; 55%; 44% and 51%, respectively. Scanning and transmission electron microscopy results revealed that endothelial damage was more prominent in EG-I when compared to EG-II. The ruptured endothelial lining and damaged cellular surface was increased in EG-I when compared to EG-II. Ultrastructural observations showed that after EPA treatment, the degeneration and cellular surface damage on the endothelium were also decreased. These biochemical and ultrastructural results suggest that EPA is a potential drug which significantly lowers the serum lipid profile and partially repairs endothelial dysfunction due to hyperlipidemia.
dc.description.sponsorshipAkdeniz University Research FoundationAkdeniz University
dc.description.sponsorshipThis article was produced by a collaborative project between the departments of Cardiovascular Surgery and Cardiology of Kosuyolu State Hospital, Istanbul; and Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya, and Department of Experimental Laboratory, Cerrahpasa Medical Faculty (Tuncay Altug), Istanbul University, Istanbul, Turkey. This study was partly funded by a grant from Akdeniz University Research Foundation. We would like to thank Gksemin Acar, Gamze Tanriover, Eylem Tuncer for their scientific support and to Sibel Ozer, Arife Demirtop and Hakan Er for their excellent technical assistance.
dc.identifier.endpage151
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.issue2en_US
dc.identifier.pmid20017101
dc.identifier.scopus2-s2.0-75149195561
dc.identifier.scopusqualityQ2
dc.identifier.startpage141
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8084
dc.identifier.volume25
dc.identifier.wosWOS:000272839100002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBerkman, Zafer
dc.language.isoen
dc.publisherF Hernandez
dc.relation.ispartofHistology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEPA
dc.subjectCholesterol
dc.subjectAtherosclerosis
dc.subjectEndothelium
dc.subjectUltrastructure
dc.subjectRabbit
dc.subjectAll-Cis-5,8,11,14,17-Icosapentaenoate Epa-E
dc.subjectPolyunsaturated Fatty-Acids
dc.subjectFish-Oil Supplementation
dc.subjectBlood-Pressure
dc.subjectEthyl All-Cis-5,8,11,14,17-Icosapentaenoate
dc.subjectPlasma-Lipids
dc.subjectDocosahexaenoic Acid
dc.subjectLipoproteins
dc.subjectVasculogenesis
dc.subjectAngiogenesis
dc.titleThe effects of Eicosapentaenoic acid on the endothelium of the carotid artery of rabbits on a high-cholesterol diet
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
8084.pdf
Boyut:
1.28 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu