Monomeric octahedral bismuth(III) benzaldehyde-N-1-alkyl thiosemicarbazones: Synthesis, characterization and biological properties

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dc.authoridGrzeskiewicz, Anita M./0000-0003-0377-2260
dc.contributor.authorAygün, Özlem
dc.contributor.authorGrzeskiewicz, Anita M.
dc.contributor.authorBanti, Christina N.
dc.contributor.authorHadjikakou, Sotiris K.
dc.contributor.authorKubicki, Maciej
dc.contributor.authorÖztürk, İbrahim İsmet
dc.date.accessioned2023-04-20T08:04:12Z
dc.date.available2023-04-20T08:04:12Z
dc.date.issued2022
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractDue to their chemical and biological properties, the interest in thiosemicarbazones and their metal complexes is increasing day by day. In this study, the effect of the substituents at the N-1 atoms of the thiosemicarbazones and the effect of halogen atoms on the type and biological properties of bismuth(III) complexes is investigated. The reactions of bismuth(III) halide with a series of benzaldehyde-N-1-alkyl-thiosemicarbazones in 1:3 M ratio yield bismuth(III) halide complexes: {BiBr3(eta(1)-S-Hbztsc)3} (1), {BiCl3(eta(1)-S-Hbzmtsc)(3)} (2), {BiBr3(eta(1)-S-Hbzmtsc)(3)} (3), {[BiCl3(eta(1)-S-Hbzetsc)(3)].CH3OH} (4) and {BiBr3(eta(1)-S-Hbzetsc)(3)} (5). Complexes 1-5 were characterized by a number of different spectroscopic methods. The crystal structures of complexes 1-5 and the free ligand benzaldehyde-N-methyl-thiosemicarbazone were determined by X-ray diffraction. Complexes 1-5 were tested for their in vitro cytotoxic activity against human breast adenocarcinoma (MCF-7) cell line. Complexes 1-5 showed low cytotoxic activity. The antibacterial activities of 1-5 and their free ligands against four strains bacteria of Staphylococcus epidermidis, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli have been examined. The results indicated that bismuth(III) complexes 1-5 are most active against E. coli and, among them, complex 4 exhibits the highest activity. Lipoxygenase (LOX) inhibitory activity of the bismuth(III) halide complexes 1-5 and the free ligands has been detected experimentally. The IC50 values indicate that bismuth(III) halide complexes 1-5 have a higher enzyme inhibition potential than free ligands and cisplatin.
dc.description.sponsorshipTekirdag Namik Kemal University, Office of Scientific Research Projects [NKUBAP.01.GA.20.281]
dc.description.sponsorshipThis study was realized in partial fulfillment of the requirements for the master thesis of Mrs. O.A., under the supervision of I.I.O. This research was promoted by the Tekirdag Namik Kemal University, Office of Scientific Research Projects (Project No. NKUBAP.01.GA.20.281) .
dc.identifier.doi10.1016/j.poly.2022.115683
dc.identifier.issn0277-5387
dc.identifier.issn1873-3719
dc.identifier.scopus2-s2.0-85123621103
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.poly.2022.115683
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11007
dc.identifier.volume215
dc.identifier.wosWOS:000779411800004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAygün, Özlem
dc.institutionauthorÖztürk, İbrahim İsmet
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPolyhedron
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBismuth(Iii) Complex
dc.subjectThiosemicarbazone
dc.subjectSpectroscopy
dc.subjectCrystal Structure
dc.subjectBiological Activity
dc.subjectChloride Complexes
dc.subjectCrystal-Structures
dc.subjectPrecursors
dc.subjectLigands
dc.titleMonomeric octahedral bismuth(III) benzaldehyde-N-1-alkyl thiosemicarbazones: Synthesis, characterization and biological properties
dc.typeArticle

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