Infection frequency may not increase in Familial Mediterranean fever

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dc.contributor.authorŞen, Nesrin
dc.contributor.authorMercan, Rıdvan
dc.contributor.authorVolkan, Ömür
dc.contributor.authorBayar, Esra
dc.contributor.authorYılmaz-öner, Sibel
dc.contributor.authorTezcan, Mehmet Engin
dc.date.accessioned2024-10-29T17:43:40Z
dc.date.available2024-10-29T17:43:40Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjective: To the best of our knowledge, there is no study evaluating the infectious features of Familial Mediterranean fever (FMF) in the literature. Here, we tested two hypotheses: infection is more common in FMF and FMF severity and infection may be linked. Methods: We included three groups: FMF (363 patients), spondyloarthropathy (SpA-patients) (112 patients) and control (121 patients). We screened participants for infection characteristics in the last year with a pre-approved and validated questionnaire. Firstly, we compared infection rates, frequency of infection types, and infection severity within groups. We then evaluated the factors associated with infection in FMF. Results: We found that infection rates were similar in FMF, SpA-patients and controls. However, admission to the infection outpatient clinic was more common in FMF (p=0.001) and the duration of workforce loss due to infection was longer in FMF than controls (p=0.002). Furthermore, FMF-patients with infection had higher disease severity (p=0.004), high acute phase reactants between attacks (p=0.006) and more site involvement during attacks (p<0.001). In multivariate analyses, the latter was found to be significant (p=0.003). Conclusion: We discovered no increase in the infection rate of FMF patients. Patients with infections, on the other hand, may have more severe FMF. © 2024 The Author. Published by Galenos Publishing House on behalf of Turkish Society for Rheumatology.
dc.identifier.doi10.4274/raed.galenos.2024.52714
dc.identifier.endpage24
dc.identifier.issn2651-2653
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85189158196
dc.identifier.scopusqualityN/A
dc.identifier.startpage15
dc.identifier.trdizinid1240060
dc.identifier.urihttps://doi.org/10.4274/raed.galenos.2024.52714
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1240060
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12551
dc.identifier.volume16
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherGalenos Publishing House
dc.relation.ispartofJournal of Turkish Society For Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAuto-inflammatory diseases
dc.subjectdisease activity
dc.subjectFamilial Mediterranean fever
dc.subjectinfection
dc.titleInfection frequency may not increase in Familial Mediterranean fever
dc.title.alternativeInfection frequency may not increase in Familial Mediterranean fever
dc.typeArticle

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