Role of GDF-15 as an inflammatory marker in patients with psoriasis vulgaris

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dc.contributor.authorTaşolar, Mustafa Kaan
dc.contributor.authorErfan, Gamze
dc.contributor.authorRaimoğlu, Onur
dc.contributor.authorAlbayrak, Hülya
dc.contributor.authorYanık, Mehmet Emin
dc.date.accessioned2022-05-11T14:37:20Z
dc.date.available2022-05-11T14:37:20Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground and Design: Psoriasis is a chronic, inflammatory disease, and several biochemical markers play role in its inflammatory process. This study measured the levels of interleukin-12 (IL-12), IL-17a, IL-22 and IL-23, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha) and serum growth differentiation factor-15 (GDF-15) and aimed to detect the relationship of serum GDF-15 level with inflammation and disease severity. Materials and Methods: This study included 50 consecutive patients diagnosed with plaque-type psoriasis. For all patients, dermatological examinations were performed, and psoriasis area severity index (PASI) scores were recorded. Patients with PASI <10 were considered to have mild (group 1), 10-20 moderate (group 2), and >20 severe (group 3) psoriasis. Results: No difference was observed between the patient and the control groups in terms of age, sex, IL-17a and IL-22. A statistically nonsignificant difference was detected in terms of IL-12 and IL-23. However, there was significant difference between two groups in terms of hs-CRP, TNF-alpha and GDF-15. GDF-15 was significantly different in all three groups (p<0.001). A significant correlation was observed between PASI score and disease duration (p=0.005), hs-CRP (p=0.003), TNF-alpha (p=0.002), and serum GDF-15 levels (p<0.001). The serum GDF-15 level that can predict a high PASI score was >1498.5 pg/mL (area under the curve: 0.813, p<0.001) in the receiver operating characteristic curve analysis. This study is mainly limited by the lack of follow-up and pre-and post-treatment assessment. Inflammatory markers were measured only in the serum, and their tissue levels are unknown. Conclusion: In addition to PASI score, GDF-15 levels can be a guide in monitoring treatment and systemic inflammation, determining the disease severity, and providing efficient treatment.
dc.identifier.doi10.4274/turkderm.galenos.2021.73444
dc.identifier.endpage188
dc.identifier.issn2717-6398
dc.identifier.issn2651-5164
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85130032493
dc.identifier.scopusqualityQ4
dc.identifier.startpage184
dc.identifier.trdizinid508319
dc.identifier.urihttps://doi.org/10.4274/turkderm.galenos.2021.73444
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8662
dc.identifier.volume55
dc.identifier.wosWOS:000753684100005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAlbayrak, Hülya
dc.language.isotr
dc.publisherDeri Zuhrevi Hastaliklar Dernegi
dc.relation.ispartofTurkderm-Turkish Archives of Dermatology and Venerology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPsoriasis vulgaris
dc.subjectPASI
dc.subjectGDF-15
dc.subjectC-Reactive Protein
dc.subjectTnf-Alpha Levels
dc.subjectSerum-Levels
dc.subjectCardiovascular Risk
dc.subjectIl-22
dc.subjectDifferentiation
dc.subjectCytokines
dc.subjectExpression
dc.subjectSeverity
dc.subjectIl-17
dc.titleRole of GDF-15 as an inflammatory marker in patients with psoriasis vulgaris
dc.typeArticle

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