Comparison of ovulation induction and pregnacy outcomes in IVF patients with normal ovarian reserve who underwent long protocol with recombinant-FSH and highly purified-hMG

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dc.authorid0000-0002-9232-8462
dc.authorscopusid24075279000
dc.authorscopusid24785274300
dc.authorscopusid35739007500
dc.authorscopusid35738457600
dc.authorscopusid6506061779
dc.authorscopusid12797008100
dc.authorscopusid36159389700
dc.authorwosidAsoglu, Mehmet Resit/O-8297-2019
dc.contributor.authorÇelik, Cem
dc.contributor.authorSofuoglu, Kenan
dc.contributor.authorSelçuk, Selcuk
dc.contributor.authorAsoğlu, Mehmet Reşit
dc.contributor.authorAbalı, Remzi
dc.contributor.authorÇetingoz, Elcin
dc.contributor.authorUludogan, Mehmet
dc.date.accessioned2022-05-11T14:35:49Z
dc.date.available2022-05-11T14:35:49Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractObjective: Gonadotropins used in controlled ovarian stimulation have been increasing in number. Beside the recombinant preparations such as rec-FSH, rec-LH and h-hMG human-derived preparations have entered the market. We decided to compare the effects of rec-FSH and HP-hMG with GnRHa on embryo quality and pregnancy outcome in women undergoing an IVF cycle. Material and Methods: In this study, data of 87 patients who had applied to our center from 2007 to 2008 and who had met all inclusion criteria, were analyzed. The patients underwent controlled ovarian hyperstimulation with HP-hMG, rec-FSH following down-regulation with a GnRHa in a long protocol, selected according to determined criteria and acquired embryo via IVF transfer. Results: Of the 87 patients, 44 were stimulated with rec-FSH and 43 with HP-hMG. Distribution of infertility causes was similar between the groups. Duration of gonadotropin administration (p=0.677, Student's t-test) and the total dose of gonadotropin received (p=0.392, Student's t-test) were similar between the two groups. The fertilization rate of the rec- FSH group was significantly higher than the HP-hMG group (p=0.001, Mann-Whitney U test). No significant differences were observed between the study groups in biochemical, clinical and ongoing pregnancy parameters. Conclusion: The higher oocyte yield with rec- FSH does not result in higher quality embryos. LH activity in combination with FSH activity positively affected the oocyte and embryo maturation. Therefore, when we consider the clinical and ongoing pregnancy rates there is no inferiority of HP-hMG in controlled ovarian stimulation.
dc.identifier.doi10.5152/jtgga.2011.04
dc.identifier.endpage20
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue1en_US
dc.identifier.pmid24591951
dc.identifier.scopus2-s2.0-79955438957
dc.identifier.scopusqualityQ3
dc.identifier.startpage15
dc.identifier.urihttps://doi.org/10.5152/jtgga.2011.04
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8248
dc.identifier.volume12
dc.identifier.wosWOS:000420637800004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelik, Cem
dc.institutionauthorAbalı, Remzi
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofJournal of the Turkish-German Gynecological Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOvarian stimulation
dc.subjectrec-FSH
dc.subjectHP-hMG
dc.subjectFollicle-Stimulating-Hormone
dc.subjectIn-Vitro Fertilization
dc.subjectHuman Menopausal Gonadotropin
dc.subjectIntracytoplasmic Sperm Injection
dc.subjectLuteinizing-Hormone
dc.subjectControlled-Trial
dc.subjectWomen
dc.subjectHyperstimulation
dc.subjectInfertility
dc.subjectOocyte
dc.titleComparison of ovulation induction and pregnacy outcomes in IVF patients with normal ovarian reserve who underwent long protocol with recombinant-FSH and highly purified-hMG
dc.title.alternativeNormal over rezervi olan ve long protokol uygulanan İVF hastalarında rekombinant fsh ve yüksek derecede saflaştırılmış hmg kullanımının gebelik sonuçlarına etkisinin karşılaştırılması]
dc.typeArticle

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