Functional characteristics of the growth factor receptor family and some ligands in the oropharyngeal cavity of the Chukar partridge (Alectoris chukar)

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dc.authorscopusid9842574500
dc.authorscopusid56521500300
dc.authorscopusid35114425000
dc.authorscopusid36650778800
dc.authorwosidErdogan, Serkan/F-5923-2011
dc.contributor.authorGüney Saruhan, Berna
dc.contributor.authorSağsöz, Hakan
dc.contributor.authorAkbalık, Mehmet Erdem
dc.contributor.authorErdoğan, Serkan
dc.date.accessioned2022-05-11T14:42:23Z
dc.date.available2022-05-11T14:42:23Z
dc.date.issued2015
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Anatomi Ana Bilim Dalı
dc.description.abstract1. The aim of the present study is to describe, immunohistochemically, the expression and cell type localisation of growth factor receptors and some of their ligands in the oropharyngeal organs of the Chukar partridge. 2. The tissue samples from 10 healthy adult partridges were dissected under ether anaesthesia and then embedded in paraffin following routine histological procedures. The immunoreaction for receptors and ligands of the epidermal growth factor receptor (EGFR)/ligand system was localised in the cell membrane, nucleus and cytoplasm of the luminal and glandular epithelial cells, stromal and striated muscle cells, and vascular endothelial and smooth muscle cells. 3. Variations were observed in the avian oropharyngeal organs. The immunostaining for the erbB1/HER1 (human epidermal growth factor receptor 1) and the EGF (epidermal growth factor) and AREG (Amphiregulin) ligands in the luminal epithelial cells was higher than in the glandular epithelial, stromal and striated muscle cells. However, the immunostaining for erbB3/HER3 (human epidermal growth factor receptor 3) and erbB4/HER4 (human epidermal growth factor receptor 4) were similar in the luminal epithelium, stromal and striated muscle cells. 4. Growth factor receptors and some of their ligands were localised in different cell types in the oropharyngeal organs. We suggest that erbB/HERs (human epidermal growth factor receptors) and their ligands play an important role in proliferation, differentiation, growth, survival and migration of the cells.
dc.identifier.doi10.1080/00071668.2015.1099611
dc.identifier.endpage686
dc.identifier.issn0007-1668
dc.identifier.issn1466-1799
dc.identifier.issue6en_US
dc.identifier.pmid26569385
dc.identifier.scopus2-s2.0-84954404208
dc.identifier.scopusqualityQ2
dc.identifier.startpage673
dc.identifier.urihttps://doi.org/10.1080/00071668.2015.1099611
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9357
dc.identifier.volume56
dc.identifier.wosWOS:000371284900009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdoğan, Serkan
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBritish Poultry Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEgf Receptor
dc.subjectNuclear-Localization
dc.subjectGray 1830
dc.subjectExpression
dc.subjectAmphiregulin
dc.subjectTongue
dc.subjectTranscription
dc.subjectEndometrium
dc.subjectNeuregulin
dc.subjectEstrogen
dc.titleFunctional characteristics of the growth factor receptor family and some ligands in the oropharyngeal cavity of the Chukar partridge (Alectoris chukar)
dc.typeArticle

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