BRAF V600E mutation in papillary thyroid cancer is correlated with adverse clinicopathological features but not with iodine exposure

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dc.authorid0000-0001-7364-370X
dc.authorid0000-0002-5839-9689
dc.authorscopusid8416126500
dc.authorscopusid56603877700
dc.authorscopusid56720914900
dc.authorscopusid57195969411
dc.authorscopusid56478832600
dc.authorscopusid56735615100
dc.authorscopusid57190950157
dc.authorwosidozcelik, melike/AAS-7557-2020
dc.authorwosidÇelik, Mehmet/AAA-8773-2021
dc.authorwosidDAYAN, AKIN/ABI-4218-2020
dc.contributor.authorÖzçelik, Serhat
dc.contributor.authorBircan, Rifat
dc.contributor.authorSarıkaya, Şükran
dc.contributor.authorGül, Aylin E.
dc.contributor.authorAydın, Büşra
dc.contributor.authorÖzçelik, Melike
dc.contributor.authorIlıksu Gözü, Hülya
dc.date.accessioned2022-05-11T14:28:40Z
dc.date.available2022-05-11T14:28:40Z
dc.date.issued2019
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractIntroduction: BRAF(V600E) activating mutation is the most frequent genetic abnormality in the pathogenesis of papillary thyroid carcinoma. We aimed to evaluate the association between BRAF(V600E )mutation and well-established prognostic clinicopathological characteristics as well as iodine exposure. Material and methods: From 2000 to 2012, the data of PTC patients admitted to Dr. Lutfi Kirdar Kartal Education and Research Hospital in Turkey were reviewed retrospectively. Clinicopathological parameters were collected. BRAF(V600E) mutation was analysed by DNA sequencing method in tumour specimens. We hypothesised that BRAF(V600E) mutation prevalence is positively correlated with prolonged iodine exposure and expected to be higher in the second half of the recruitment period due to the increment in time spent from the iodisation process of the table salt in our country. Thus, iodine exposure was categorised as short-term (2000-2006) and long-term (2006-2012). Results: A total of 197 patients were accrued. The study population predominantly consisted of conventional variant. A statistically significant relationship was observed between BRAF(V600E) mutation presence and age (p = 0.03), conventional variant PTC (p = 0.00002), T4 stage (p= 0.002), vascular invasion (p= 0.036), thyroid capsule invasion (p < 0.00001), extrathyroidal tissue invasion (p < 0.00001), and lymph node metastasis (p < 0.00001). When categorised as long-term and short-term, iodine exposure was not statistically significantly related with BRAF(V600E) mutation; however, there were far more PTC cases in the long-term group (86.3% vs. 13.7%). Conclusion: We revealed that BRAF(V600E) mutation is associated with adverse clinicopathological parameters. There appeared to be no relation between long-term iodine exposure and BRAF(V600E).
dc.description.sponsorshipResearch Fund of the Tekirdag Namik Kemal University [NKUBAP.01, YL.16.021]
dc.description.sponsorshipThis work was supported by a grant of the Research Fund of the Tekirdag Namik Kemal University (Project number: NKUBAP.01.YL.16.021).
dc.identifier.doi10.5603/EP.a2019.0025
dc.identifier.endpage408
dc.identifier.issn0423-104X
dc.identifier.issue5en_US
dc.identifier.pmid31135058
dc.identifier.scopus2-s2.0-85074445957
dc.identifier.scopusqualityQ3
dc.identifier.startpage401
dc.identifier.urihttps://doi.org/10.5603/EP.a2019.0025
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6905
dc.identifier.volume70
dc.identifier.wosWOS:000495373700004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBircan, Rifat
dc.institutionauthorAydın, Büşra
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofEndokrynologia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectpapillary thyroid cancer
dc.subjectBRAF V600E
dc.subjectiodine
dc.subjectBraf V600e Mutation
dc.subjectBraf(V600e) Mutation
dc.subjectPrevalence
dc.subjectCarcinoma
dc.subjectAssociation
dc.subjectRecurrence
dc.subjectGene
dc.titleBRAF V600E mutation in papillary thyroid cancer is correlated with adverse clinicopathological features but not with iodine exposure
dc.typeArticle

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