Kronik Obstrüktif Akciğer Hastalığı Olan Hastalarda Kognitif Fonksiyonların Değerlendirilmesi

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dc.authorscopusid15122124600
dc.authorscopusid6603040523
dc.authorscopusid8917314800
dc.authorscopusid7004457653
dc.authorscopusid6701664192
dc.authorscopusid6602412924
dc.authorscopusid6603267445
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorBüyükkoyuncu Pekel, Nilüfer
dc.contributor.authorTurgut, Nilda
dc.contributor.authorAltıay, Gündeniz
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorTurgut, Burhan
dc.contributor.authorErbaş, Hakan
dc.contributor.authorSüt, Necdet
dc.date.accessioned2022-05-11T14:39:56Z
dc.date.available2022-05-11T14:39:56Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Chronic obstructive pulmonary disease (COPD) is characterized with air flow limitation. Cognitive problems can appear in advanced stage of COPD. There is relationship between COPD and levels of homocystein (hcy) and total antioxidant capacity (TAC). There is also relationship between cognitive dysfunction and levels of hcy and TAC. We aimed evaluation of cognitive functions in patients with COPD, and demonstration of the relationship between cognitive function and hcy and TAC. Methods: Twenty-eight hypoxic (group 1), 28 non-hypoxic COPD patients (group 2) and 25 healthy people (control group, group 3) were included to study. Hcy and TAC levels were measured in all subjects. Cognitive functions were evaluated in all subjects with standardized mini mental test (SMMT), clock drawing test (CDT), Blessed orientation memory concentration test (BOMCT), Benton's facial recognition test (BFRT) and clinical dementia rating scale (CDRS). Results: Hcy levels were high in group 1 (p=0.004), TAC levels were high in group 1 and 2 (p=0.04). SMMT (p=0.000) and CDT values were low in group1 (p=0.000), CDRS values were high in group1 and 2 (p=0.000), BFRT values were low in group1 and 2 (p=0.000), BOMCT values were high in group1 (p=0.000). There were a correlation between TAC and SMMT (r=0.582, p=0.001) and CDRS (r=-0.384, p=0.044). Conclusions: We demonstrated presence of cognitive dysfunction in COPD patients. Patients with hypoxic had more profound cognitive dysfunction. In addition, we demonstrated a relationship between TAC and cognitive dysfunction.
dc.identifier.doi10.5350/BTDMJB.20171228110902
dc.identifier.endpage114
dc.identifier.issn1305-9319
dc.identifier.issn1305-9327
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85044762055
dc.identifier.scopusqualityQ4
dc.identifier.startpage109
dc.identifier.urihttps://doi.org/10.5350/BTDMJB.20171228110902
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8803
dc.identifier.volume14
dc.identifier.wosWOS:000431943800017
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTurgut, Nilda
dc.language.isotr
dc.publisherYerkure Tanitim & Yayincilik Hizmetleri A S
dc.relation.ispartofMedical Journal of Bakirkoy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChronic obsructive pulmonary disease
dc.subjectcognitive tests
dc.subjecthomocysteine
dc.subjecttotal antioxidant capacity
dc.subjectOxidative Stress
dc.subjectAlzheimers-Disease
dc.subjectHomocysteine
dc.subjectCopd
dc.subjectAntioxidants
dc.subjectImpairment
dc.subjectPerformance
dc.subjectPopulation
dc.subjectApoptosis
dc.subjectSmoking
dc.titleKronik Obstrüktif Akciğer Hastalığı Olan Hastalarda Kognitif Fonksiyonların Değerlendirilmesi
dc.title.alternativeCognitive dysfunction in patients with chronic obstructive pulmonary disease
dc.typeArticle

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