The effectiveness of the ketogenic diet in drug-resistant childhood epilepsy

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dc.authorscopusid55505087800
dc.authorscopusid57194536020
dc.authorscopusid57218497940
dc.authorscopusid55893744000
dc.authorscopusid57210973159
dc.authorscopusid57206202714
dc.authorscopusid57194747070
dc.contributor.authorYılmaz, Ünsal
dc.contributor.authorEdizer, Selvinaz
dc.contributor.authorAkışın, Zeynep
dc.contributor.authorKöse, Melis
dc.contributor.authorGüzin, Yiğithan
dc.contributor.authorGürbüz, Gürkan
dc.contributor.authorÜnalp, Aycan
dc.date.accessioned2023-04-20T08:01:17Z
dc.date.available2023-04-20T08:01:17Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description2nd International Behcet Uz Children's Congress -- MAR 04-07, 2020 -- Izmir, TURKEY
dc.description.abstractBackground. We aimed to investigate the effectiveness of ketogenic diet (KD) in children with various types of refractory epilepsy. Methods. A total of 91 children (49 females) aged 3 to 193 months (median, 52 months) with drug resistant epilepsy who received KD treatment for at least 12 months were enrolled in the study. Seizure frequency, adherence to diet, reason for discontinuation of KD, and adverse effects were recorded. Response was defined as >= 50% improvement in seizure frequency compared to baseline. We also searched for influences of different variables on the outcome. Results. Intent-to-treat analysis revealed an improvement in seizure frequency for >= 50% in 73.6%, 80.2%, 75.8%, 73.6%, and 70.3% of patients at month-1,-3,-6,-9, and month-12, respectively. Overall, 32 (35.2%) patients remained seizure-free at month-12. There was no significant differences between responders and non responders in terms of age at onset of epilepsy, age at onset of KD, gender, or etiology. Mild hyperlipidemia was associated with a higher response rate. At the last follow-up (median: 20 months), 38 (41.8%) patients were still maintained on KD. While 15.4% of patients completed the diet with a success in seizure control, remainder discontinued KD due to lack of efficacy (23.1%), non-adharence to diet (11%), intercurrent infection (4.4%), adverse effects (3.3%), and death (1.1%). Conclusion. Ketogenic diet treatment appears to be effective in about two-thirds of children with various types of drug-resistant epilepsy, including one-third remaining seizure free. Mild hyperlipidemia seems to be associated with a higher response rate. Discontinuation of KD is mostly due to lack of efficacy or nonadherence, and rarely side effects.
dc.identifier.doi10.24953/turkjped.2021.4
dc.identifier.endpage220
dc.identifier.issn0041-4301
dc.identifier.issue2en_US
dc.identifier.pmid35611409
dc.identifier.scopus2-s2.0-85130993431
dc.identifier.scopusqualityQ3
dc.identifier.startpage210
dc.identifier.trdizinid1141197
dc.identifier.urihttps://doi.org/10.24953/turkjped.2021.4
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10851
dc.identifier.volume64
dc.identifier.wosWOS:000802228700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGürbüz, Gürkan
dc.language.isoen
dc.publisherTurkish J Pediatrics
dc.relation.ispartofTurkish Journal of Pediatrics
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKetogenic Diet
dc.subjectDrug-Resistant Epilepsy
dc.subjectEffectiveness
dc.subjectTolerability
dc.subjectIlae Commission
dc.subjectRefractory Epilepsy
dc.subjectTreatment Option
dc.subjectPosition Paper
dc.subjectEfficacy
dc.subjectTolerability
dc.subjectSafety
dc.subjectClassification
dc.subjectComplications
dc.subjectExperience
dc.titleThe effectiveness of the ketogenic diet in drug-resistant childhood epilepsy
dc.typeConference Object

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