Histopathological and immunohistochemical investigation of the local and systemic effects of tranexamic acid on the healing of the Achilles tendon in rats

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dc.authorid0000-0001-6576-1802
dc.authorid0000-0003-3416-5666
dc.authorscopusid57221924322
dc.authorscopusid55994580900
dc.authorscopusid56904163300
dc.authorscopusid57221927685
dc.authorwosidDinçel, Yaşar Mahsut/AAB-8340-2019
dc.authorwosidsari, abdulkadir/ABH-3293-2021
dc.authorwosidsari, abdulkadir/AAF-3143-2021
dc.authorwosidçetin, mehmet ümit/AAA-4905-2022
dc.contributor.authorSarı, Abdulkadir
dc.contributor.authorDinçel, Yaşar Mahsut
dc.contributor.authorKarabağ, Sevil
dc.contributor.authorÇetin, Mehmet Ümit
dc.date.accessioned2022-05-11T14:12:30Z
dc.date.available2022-05-11T14:12:30Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractObjectives: This study aims to compare the effects of systemic and local applications of tranexamic acid (TXA) on tendon healing using a rat Achilles tendon injury model. Patients and methods: Thirty-six adult male albino Wistar rats (aging 3-4 months; weighing 350 to 400 g) were used in this study conducted between December 2019 and January 2020. The Achilles tendon was performed bilateral tenotomy and surgically repaired. Postoperatively, 1 mL of TXA was administered to each leg locally in the local group, whereas 2 mL of TXA was intraperitoneally administered in the systemic group. The control group was left untreated. Half of the rats were sacrificed on Day 15 and the other half on Day 30. Tendon healing was evaluated with the Bonar and the Movin scoring systems and immunohistochemical methods. Results: The systemic group had the highest Bonar and Movin scores on Day 15. All groups exhibited tendon healing on Day 30, with no significant differences among the groups. The tenocyte morphology was found to be more impaired in both TXA groups on Day 30 (p=0.013). Ground substance scores were lower in the systemic group on Day 30 (p=0.028). The fiber structure and arrangement scores were higher in the systemic group on Day 15 (p=0.007 and p=0.032). Immunohistochemical analyses showed that galectin-3 values exhibited a significant difference in all groups on Day 30 (p=0.020). In all groups, it was determined that type I collagen values showed an increasing trend on Day 30, compared to the values on Day 15, whereas type III collagen values showed a decreasing trend. Conclusion: Our results demonstrated that local and systemic use of TXA does not impair tendon healing. Although advanced studies are needed, our study suggests that TXA application reduces the development of fibrosis.
dc.identifier.doi10.5606/ehc.2021.76301
dc.identifier.endpage161
dc.identifier.issn2687-4784
dc.identifier.issn2687-4792
dc.identifier.issue1en_US
dc.identifier.pmid33463431
dc.identifier.scopus2-s2.0-85100129243
dc.identifier.scopusqualityQ2
dc.identifier.startpage152
dc.identifier.urihttps://doi.org/10.5606/ehc.2021.76301
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5583
dc.identifier.volume32
dc.identifier.wosWOS:000608440400022
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSarı, Abdulkadir
dc.institutionauthorDinçel, Yaşar Mahsut
dc.institutionauthorKarabağ, Sevil
dc.institutionauthorÇetin, Mehmet Ümit
dc.language.isoen
dc.publisherTurkish Joint Diseases Foundation
dc.relation.ispartofJoint Diseases and Related Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAchilles tendon
dc.subjecthistopathology
dc.subjectimmunohistochemical
dc.subjectrat
dc.subjecttranexamic acid
dc.subjectRisk
dc.titleHistopathological and immunohistochemical investigation of the local and systemic effects of tranexamic acid on the healing of the Achilles tendon in rats
dc.typeArticle

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