Visceral to subcutaneous fat ratio predicts short-term mortality in patients with Covid 19. A multicenter study

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dc.authorscopusid35585658600
dc.authorscopusid57224572940
dc.authorscopusid57416884700
dc.authorscopusid57761613400
dc.authorscopusid56671355500
dc.authorscopusid57224775809
dc.authorscopusid57190971463
dc.contributor.authorSurov, A.
dc.contributor.authorThormann, M.
dc.contributor.authorKardaş, H.
dc.contributor.authorHinnerichs, M.
dc.contributor.authorOmari, J.
dc.contributor.authorCingöz, E.
dc.contributor.authorCingöz, M.
dc.contributor.authorChousein, O.
dc.contributor.authorSasani, Hadi
dc.contributor.authorGönen, Korcan Aysun
dc.date.accessioned2023-05-06T17:23:35Z
dc.date.available2023-05-06T17:23:35Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalı
dc.description.abstractObjective: To evaluate the association of body composition parameters with outcomes in Covid-19. Methods: 173 patients hospitalized for Covid-19 infection in 6 European centers were included in this retrospective study. Measurements were performed at L3-level and comprised skeletal muscle index (SMI), muscle density (MD), and adipose tissue measurements [visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), intramuscular adipose tissue (IMAT), visceral-to-subcutaneous-adipose-tissue-area-ratio (VSR)]. The association with mortality, the need for intubation (MV), and the need for admission to ICU within 30 days were evaluated. Results: Higher SAT density was associated with a greater risk of MV (OR = 1.071, 95%CI=(1.034;1.110), p < 0.001). Higher VAT density was associated with admission to ICU (OR = 1.068, 95%CI=(1.029;1.109), p < 0.001). Higher MD was a protective factor for MV and ICU admission (OR = 0.914, 95%CI=(0.870;0.960), p < 0.001; OR = 0.882, 95%CI=(0.832;0.934), p = 0.028). Higher VSR was associated with mortality (OR = 2.147, 95%CI=(1.022;4.512), p = 0.044). Male sex showed the strongest influence on the risk of ICU admission and MV. SMI was not associated with either parameter. Conclusion: In patients hospitalized for Covid-19 infection, higher VSR seems to be a strong prognostic factor of short-term mortality. Weak associations with clinical course were found for MD and adipose tissue measurements. Male sex was the strongest prognostic factor of adverse clinical course. Advances in knowledge: VSR is a prognostic biomarker for 30-day mortality in patients hospitalized for Covid-19 disease. © 2023 The Authors.
dc.description.sponsorship01KX2021; Bundesministerium für Bildung und Forschung, BMBF
dc.description.sponsorshipThis research was supported by the German Federal Ministry of Education and Research (BMBF) as part of the University Medicine Network (Project RACOON, 01KX2021).
dc.identifier.doi10.1259/bjr.20220869
dc.identifier.issn0007-1285
dc.identifier.issue1144en_US
dc.identifier.pmid36744766
dc.identifier.scopus2-s2.0-85150751153
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1259/bjr.20220869
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12169
dc.identifier.volume96
dc.identifier.wosWOS:000983400100009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorChousein, O.
dc.institutionauthorSasani, Hadi
dc.institutionauthorGönen, Korcan Aysun
dc.language.isoen
dc.publisherBritish Institute of Radiology
dc.relation.ispartofBritish Journal of Radiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectadipose tissue
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectanthropometric parameters
dc.subjectArticle
dc.subjectbody composition
dc.subjectbody composition parameters
dc.subjectcomputer assisted tomography
dc.subjectcontrolled study
dc.subjectcoronavirus disease 2019
dc.subjectfemale
dc.subjecthospital admission
dc.subjecthospital patient
dc.subjecthuman
dc.subjectintensive care unit
dc.subjectintra-abdominal fat
dc.subjectintramuscular fat
dc.subjectintubation
dc.subjectlumbar spine
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmeasurement
dc.subjectmortality
dc.subjectmulticenter study
dc.subjectmuscle mass
dc.subjectpandemic
dc.subjectprediction
dc.subjectprognosis
dc.subjectretrospective study
dc.subjectrisk
dc.subjectsex difference
dc.subjectskeletal muscle
dc.subjectsubcutaneous fat
dc.subjectvisceral to subcutaneous adipose tissue ratio
dc.subjectclinical trial
dc.subjectdiagnostic imaging
dc.subjectdisease exacerbation
dc.subjectintra-abdominal fat
dc.subjectsubcutaneous fat
dc.subjectAdipose Tissue
dc.subjectCOVID-19
dc.subjectDisease Progression
dc.subjectHumans
dc.subjectIntra-Abdominal Fat
dc.subjectMale
dc.subjectRetrospective Studies
dc.subjectSubcutaneous Fat
dc.titleVisceral to subcutaneous fat ratio predicts short-term mortality in patients with Covid 19. A multicenter study
dc.typeArticle

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