Visceral to subcutaneous fat ratio predicts short-term mortality in patients with Covid 19. A multicenter study
Yükleniyor...
Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
British Institute of Radiology
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To evaluate the association of body composition parameters with outcomes in Covid-19. Methods: 173 patients hospitalized for Covid-19 infection in 6 European centers were included in this retrospective study. Measurements were performed at L3-level and comprised skeletal muscle index (SMI), muscle density (MD), and adipose tissue measurements [visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), intramuscular adipose tissue (IMAT), visceral-to-subcutaneous-adipose-tissue-area-ratio (VSR)]. The association with mortality, the need for intubation (MV), and the need for admission to ICU within 30 days were evaluated. Results: Higher SAT density was associated with a greater risk of MV (OR = 1.071, 95%CI=(1.034;1.110), p < 0.001). Higher VAT density was associated with admission to ICU (OR = 1.068, 95%CI=(1.029;1.109), p < 0.001). Higher MD was a protective factor for MV and ICU admission (OR = 0.914, 95%CI=(0.870;0.960), p < 0.001; OR = 0.882, 95%CI=(0.832;0.934), p = 0.028). Higher VSR was associated with mortality (OR = 2.147, 95%CI=(1.022;4.512), p = 0.044). Male sex showed the strongest influence on the risk of ICU admission and MV. SMI was not associated with either parameter. Conclusion: In patients hospitalized for Covid-19 infection, higher VSR seems to be a strong prognostic factor of short-term mortality. Weak associations with clinical course were found for MD and adipose tissue measurements. Male sex was the strongest prognostic factor of adverse clinical course. Advances in knowledge: VSR is a prognostic biomarker for 30-day mortality in patients hospitalized for Covid-19 disease. © 2023 The Authors.
Açıklama
Anahtar Kelimeler
adipose tissue, adolescent, adult, aged, anthropometric parameters, Article, body composition, body composition parameters, computer assisted tomography, controlled study, coronavirus disease 2019, female, hospital admission, hospital patient, human, intensive care unit, intra-abdominal fat, intramuscular fat, intubation, lumbar spine, major clinical study, male, measurement, mortality, multicenter study, muscle mass, pandemic, prediction, prognosis, retrospective study, risk, sex difference, skeletal muscle, subcutaneous fat, visceral to subcutaneous adipose tissue ratio, clinical trial, diagnostic imaging, disease exacerbation, intra-abdominal fat, subcutaneous fat, Adipose Tissue, COVID-19, Disease Progression, Humans, Intra-Abdominal Fat, Male, Retrospective Studies, Subcutaneous Fat
Kaynak
British Journal of Radiology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
96
Sayı
1144
