ASSESSMENT OF THE RELATIONSHIP BETWEEN PREDIABETES AND LOW MUSCLE MASS BASED ON BLOOD CREATININE LEVEL

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Küçük Resim

Tarih

2022

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Russian Association of Endocrinologists

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

BACKGROUND: Low muscle mass increases the risk of developing type 2 diabetes mellitus (DM 2) and prediabetes. Nutrition is an important factor in the study of the relationship between low muscle mass and the development of glucose metabolic disorders. AIM: The present study was conducted to assess the relationship between prediabetes and low muscle mass on the basis of serum creatinine levels, taking into account patient nutrition. MATERIALS AND METHODS: The study included 551 patients aged 18–69 years without DM 2. The glucose level was determined based on fasting glucose and after an oral glucose tolerance test (OGTT). Hyperglycemia is assessed according to the classification of the World Health Organization. The MedDietScore questionnaire was used to assess the nutritional factor, which determines the adherence of patients to the Mediterranean diet. In order to assess odds ratios (OR) and 95% confidence interval (CI), a binary logistic regression was performed. RESULTS: The prevalence of prediabetes in the group with the lowest and highest blood creatinine level was 31.9% and 17.5% respectively (p=0.016). As a result of the conducted regression analysis, a statistically significant relationship was found between low creatinine levels and the chances of having prediabetes (crude OR 2,07, 95% CI 1,21; 3,56), which persisted after adjusting for socio-demographic, anthropometric factors, stress level and physical activity as well as muscle strength. After adding the data on MedDietScore to the statistical model, the revealed relationship was lost (p = 0.187). CONCLUSION: Low serum creatinine increases the chances of the presence of prediabet regardless of gender, age, body weight index, the volume of the hips, the ratio of the volume of the waist to growth, as well as physical activity, the level of stress and muscular power. However, the chances of the presence of prediabet do not differ in persons with low creatinine blood depending on the commitment to the Mediterranean diet among the population of those living in the Turkestan region. © 2022 Russian Association of Endocrinologists. All rights reserved.

Açıklama

Anahtar Kelimeler

creatinine, Mediterranean diet, muscle mass, prediabetes, prediabetic condition, creatinine, glucose, adult, aged, anthropometric parameters, Article, body weight, clinical assessment, creatinine blood level, fasting blood glucose level, female, gender, hip volume, human, hyperglycemia, impaired glucose tolerance, logistic regression analysis, major clinical study, male, meddietscore questionnaire, Mediterranean diet, muscle mass, muscle strength, muscle stress, nutrition, nutritional assessment, nutritional status, oral glucose tolerance test, patient compliance, physical activity, prevalence, sociodemographics, statistical model, waist volume to growth ratio, World Health Organization

Kaynak

Diabetes Mellitus

WoS Q Değeri

N/A

Scopus Q Değeri

Q4

Cilt

25

Sayı

3

Künye