Comparison of endothelial function of coronary artery bypass grafts in diabetic and nondiabetic patients: Which graft offers the best?

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dc.authorscopusid55317577700
dc.authorscopusid10139012600
dc.authorscopusid14008084500
dc.authorscopusid56803786300
dc.authorscopusid56182776400
dc.authorscopusid57197051921
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorGür, Özcan
dc.contributor.authorGürkan, Selami
dc.contributor.authorÇömez, Selcem
dc.contributor.authorGonultas, Aylin
dc.contributor.authorYılmaz, Murat
dc.date.accessioned2022-05-11T14:10:05Z
dc.date.available2022-05-11T14:10:05Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Diabetes associated endothelial dysfunction, which determines both long and short term graft patency, is not uniform in all coronary artery bypass surgery (CABG) grafts. Herein this study, we aimed to investigate the degree of endothelial dysfunction in diabetic radial artery (RA), internal mammarian artery (IMA) and saphenous vein (SV) grafts in vitro tissue bath system. Methods: This is a prospective experimental study. Fifteen diabetic and 15 non-diabetic patients were included to the study. A total number of 96 graft samples were collected; 16 graft samples for each graft type from both diabetic and non-diabetic patients. Arterial grafts were harvested with pedicles and SV grafts were harvested by 'no touch' technique. Vasodilatation response of vascular rings to carbachol, which induces nitric oxide (NO) mediated vasodilatation, was designated as the measure of endothelial function. Results: The IMA grafts had the most prominent NO mediated vasodilatation in both diabetic and non-diabetic patients, concluding a better preserved endothelial function than SV and RA. The 'no-touch' SV and RA grafts had similar vasodilatation responses in non-diabetic patients. In diabetic patients, on the other hand, RA grafts exhibited the least vasodilatation response (ie. worst endothelial function), even less vasodilatation than 'no touch' SV grafts (p<0.0001). Conclusion: Deteriorated function of RA grafts in diabetic patients, even worse than SV grafts made evident by this study, encourages the use of 'no touch' technique as the method of SV harvesting and more meticulous imaging of RA before its use as a graft in diabetic patients.
dc.identifier.doi10.5152/akd.2014.5613
dc.identifier.endpage662
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue8en_US
dc.identifier.pmid26301347
dc.identifier.scopus2-s2.0-84988490282
dc.identifier.scopusqualityQ3
dc.identifier.startpage657
dc.identifier.urihttps://doi.org/10.5152/akd.2014.5613
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5276
dc.identifier.volume15
dc.identifier.wosWOS:000360292000012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGür, Özcan
dc.institutionauthorGürkan, Selami
dc.institutionauthorÇömez, Selcem
dc.institutionauthorYılmaz, Murat
dc.language.isoen
dc.publisherTurkish Soc Cardiology
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectendothelial function
dc.subjectcoronary artery bypass grafts
dc.subjecttissue bath study
dc.subjectInternal Thoracic Artery
dc.subjectSaphenous-Vein Grafts
dc.subjectRadial-Artery
dc.subjectMellitus
dc.subjectConduit
dc.subjectSurgery
dc.subjectSurvival
dc.subjectPatency
dc.subjectQuality
dc.subjectTool
dc.titleComparison of endothelial function of coronary artery bypass grafts in diabetic and nondiabetic patients: Which graft offers the best?
dc.typeArticle

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