Stathmin 1 and p53 Expression in Cutaneous Squamous Cell Carcinoma and Precursor Lesions

Simple item page
dc.contributor.authorÖzge, Zorlu
dc.contributor.authorSevil, Karabağ
dc.contributor.authorAhmet, Yolcu
dc.contributor.authorHülya, Albayrak
dc.contributor.authorSema, Aytekin
dc.date.accessioned2023-05-06T17:19:34Z
dc.date.available2023-05-06T17:19:34Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractStudies on the relationship between stathmin 1 (STMN1) and cutaneous squamous cell carcinoma (cSCC) are limited. We aimed to evaluate the relationship between clinicopathological factors and STMN1 and p53 expressions in cSCC and compare them with those in the precursor lesions of cSCC and normal tissue. A total of 195 patients, followed between January 2014 and December 2021, with diagnoses of primary cSCC (n = 129), in situ cSCC (n = 20), or actinic keratosis (n = 46), as well as 29 histopathologically normal tissue samples, were included in the study. Immunohistochemical staining for STMN1 and p53 was performed. In the cSCC group, STMN1 scores were higher in poorly differentiated (P = 0.001) and ulcerated (P < 0.001) tumors. A linear relationship between STMN1 score and tumor area, tumor thickness, and mitosis was found (P = 0.001, P = 0.003, and P < 0.001, respectively). There was no statistically significant correlation between STMN1 and p53 scores. Our results support the previous view that STMN1 may be associated with some adverse clinicopathological and high-risk features of cSCC. To the best of our knowledge, this is the first and largest study to investigate STMN1 expression in cSCC, precancerous lesions of cSCC, and normal tissues.
dc.identifier.doi10.1097/DAD.0000000000002381
dc.identifier.endpage175
dc.identifier.issn0193-1091
dc.identifier.issn1533-0311
dc.identifier.issue3en_US
dc.identifier.pmid36749137
dc.identifier.scopus2-s2.0-85148250068
dc.identifier.scopusqualityQ3
dc.identifier.startpage170
dc.identifier.urihttps://doi.org/10.1097/DAD.0000000000002381
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11852
dc.identifier.volume45
dc.identifier.wosWOS:000933632800007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzge, Zorlu
dc.institutionauthorSevil, Karabağ
dc.institutionauthorAhmet, Yolcu
dc.institutionauthorHülya, Albayrak
dc.institutionauthorSema, Aytekin
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofAmerican Journal Of Dermatopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectskin cancer
dc.subjectSCC
dc.subjectstathmin
dc.subjectp53
dc.subjectOverexpression
dc.subjectRisk
dc.subjectMetastasis
dc.subjectPrognosis
dc.subjectSurvival
dc.subjectP16
dc.titleStathmin 1 and p53 Expression in Cutaneous Squamous Cell Carcinoma and Precursor Lesions
dc.typeArticle

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu

We collect and process your personal information for the following purposes: Authentication, Preferences, Acknowledgement and Statistics.
To learn more, please read our privacy policy.

Customize