Stathmin 1 and p53 Expression in Cutaneous Squamous Cell Carcinoma and Precursor Lesions
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Studies on the relationship between stathmin 1 (STMN1) and cutaneous squamous cell carcinoma (cSCC) are limited. We aimed to evaluate the relationship between clinicopathological factors and STMN1 and p53 expressions in cSCC and compare them with those in the precursor lesions of cSCC and normal tissue. A total of 195 patients, followed between January 2014 and December 2021, with diagnoses of primary cSCC (n = 129), in situ cSCC (n = 20), or actinic keratosis (n = 46), as well as 29 histopathologically normal tissue samples, were included in the study. Immunohistochemical staining for STMN1 and p53 was performed. In the cSCC group, STMN1 scores were higher in poorly differentiated (P = 0.001) and ulcerated (P < 0.001) tumors. A linear relationship between STMN1 score and tumor area, tumor thickness, and mitosis was found (P = 0.001, P = 0.003, and P < 0.001, respectively). There was no statistically significant correlation between STMN1 and p53 scores. Our results support the previous view that STMN1 may be associated with some adverse clinicopathological and high-risk features of cSCC. To the best of our knowledge, this is the first and largest study to investigate STMN1 expression in cSCC, precancerous lesions of cSCC, and normal tissues.
Açıklama
Anahtar Kelimeler
skin cancer, SCC, stathmin, p53, Overexpression, Risk, Metastasis, Prognosis, Survival, P16
Kaynak
American Journal Of Dermatopathology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
45
Sayı
3
