Novel bismuth compounds: synthesis, characterization and biological activity against human adenocarcinoma cells

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dc.authorid0000-0003-3264-2406
dc.authorid0000-0001-9556-6266
dc.authorid0000-0003-3164-0038
dc.authorid0000-0001-6727-2711
dc.authorscopusid6602100613
dc.authorscopusid36785856200
dc.authorscopusid46860923200
dc.authorscopusid6507202525
dc.authorscopusid14525091600
dc.authorscopusid57193876716
dc.authorscopusid6602925165
dc.authorwosidKourkoumelis, Nikolaos/B-8555-2009
dc.authorwosidHadjikakou, Sotiris K./I-2909-2019
dc.authorwosidOzturk, Ibrahim Ismet/K-1352-2013
dc.contributor.authorArda, M.
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorBanti, Christina N.
dc.contributor.authorKourkoumelis, Nikolaos
dc.contributor.authorManoli, Maria
dc.contributor.authorTasiopoulos, Anastasios J.
dc.contributor.authorHadjikakou, Sotiris K.
dc.date.accessioned2022-05-11T14:30:55Z
dc.date.available2022-05-11T14:30:55Z
dc.date.issued2016
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractFive new bismuth(III) halide compounds (BiX3, X = Br or I) of formulae {[BiBr(Me2DTC)(2)](n)} (1), {[BiBr2(Et2DTC)](n)} (2), {[BiI2(Me2DTC)](n)} (3), {[BiI(Et2DTC)(2)](n)} (4) and {[BiI(mu(2)-I)(Et2DTC)(2)](2)}(n) (5) (Me2DTCH = dimethyldithiocarbamate, C3H7NS2 and Et2DTCH = diethyldithiocarbamate, C5H11NS2) were synthesized from the reactions between bismuth(III) bromide (BiBr3) or bismuth(III) iodide (BiI3) with tetramethylthiuram monosulfide (Me(4)tms), tetramethylthiuram disulfide (Me(4)tds) or tetraethylthiuram disulfide (Et(4)tds). The complexes were characterized by melting point, elemental analysis, FT-IR spectroscopy, Raman spectroscopy, H-1, C-13 NMR spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TG-DTA). Moreover, the crystal structures of 1-5 were determined with single crystal X-ray diffraction analysis. The ligands of compounds 1-5 were derived from reduction with concomitant degradation to dithiocarbamates. Complexes 1-4 are polymers, whereas complex 5 is a dimer, built up from monomeric units with square pyramidal (SP) geometry (1, 4 and 5) and pentagonal bipyramidal geometry (2 and 3) around the bismuth center. Complexes 1-5 were evaluated for their in vitro cytotoxic activity against human adenocarcinoma breast (MCF-7) and cervix (HeLa) cells. The toxicity on normal human fetal lung fibroblast cells (MRC-5) is also evaluated. Since estrogen receptors (ERs) are located in MCF-7, in contrast to HeLa cells, the estrogenic effect of 1-5 on MCF-7 cells was studied by means of a methylene blue assay. Hirshfeld surface volumes were analyzed to clarify the nature of the intermolecular interactions. Molecules with lower H-all atoms inter-molecular interactions tend to exhibit higher activity against both MCF-7 and HeLa cells. Structure-activity relationship (SAR) studies were performed for these complexes using 2D topological based disparity analysis. This finding underlines the significance of the halogen atoms in the coordination sphere of the metal ion.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z534]; National Scholarships Foundation of Greece (IKY)
dc.description.sponsorshipThis research was carried out in partial fulfillment of the requirements for the master thesis of M. A. under the supervision of I. I. O. I. I. O. and M. A. acknowledge the financial support from The Scientific and Technological Research Council of Turkey (TUBITAK, Project No. 113Z534). CNB and SKH would like to thank the Unit of bioactivity testing of xenobiotics, the University of Ioannina, for providing access to the facilities. CNB and SKH acknowledge the National Scholarships Foundation of Greece (IKY) for the post doctoral research fellowship of excellence programm IKY-Siemens.
dc.identifier.doi10.1039/c6ra01181k
dc.identifier.endpage29044
dc.identifier.issn2046-2069
dc.identifier.issue35en_US
dc.identifier.scopus2-s2.0-85017287909
dc.identifier.scopusqualityQ2
dc.identifier.startpage29026
dc.identifier.urihttps://doi.org/10.1039/c6ra01181k
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7232
dc.identifier.volume6
dc.identifier.wosWOS:000373029500003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorArda, M.
dc.institutionauthorÖztürk, İbrahim İsmet
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofRsc Advances
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntimony(Iii) Halide-Complexes
dc.subjectCrystal-Structure
dc.subjectIn-Vitro
dc.subjectStructural-Characterization
dc.subjectMolecular-Structure
dc.subjectEstrogen-Receptor
dc.subjectVibrational-Spectra
dc.subjectBromide Complexes
dc.subjectThiuram Sulfides
dc.subjectDithiocarbamate
dc.titleNovel bismuth compounds: synthesis, characterization and biological activity against human adenocarcinoma cells
dc.typeArticle

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