Antioxidant and Tyrosinase Inhibitory Activities of Flavonoids from Trifolium nigrescens Subsp petrisavi

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dc.authorid0000-0002-7946-6545
dc.authorid0000-0001-8932-4535
dc.authorid0000-0002-7946-6545
dc.authorid0000-0003-4384-4265
dc.authorscopusid26029065100
dc.authorscopusid6505866652
dc.authorscopusid7102665882
dc.authorscopusid7006671101
dc.authorwosidTopcu, Gulacti/AAH-8305-2019
dc.authorwosidÖztürk, Mehmet/W-4649-2017
dc.authorwosidSABUDAK, Temine/AAG-6784-2019
dc.authorwosidTopcu, Gulacti/C-8344-2015
dc.contributor.authorDemirkiran, Özlem
dc.contributor.authorŞabudak, Temine
dc.contributor.authorÖztürk, Mehmet
dc.contributor.authorTopçu, Gülacti
dc.date.accessioned2022-05-11T14:29:49Z
dc.date.available2022-05-11T14:29:49Z
dc.date.issued2013
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractTrifolium nigrescens was researched for its chemical constituents for the first time. Bioassay-guided isolation of the EtOAc extract from the leaves of T. nigrescens resulted in the purification of a new biflavone, 4',5,5 '',7,7 ''-pentahydroxy-3',3'-dimethoxy-3-O-beta-D-glucosyl-3 '',4'-O-biflavone (1) along with eleven known compounds consisting of three phenolics (2-4), and eight flavonoid glycosides (5-12). Their structures were determined by extensive ID and 2D NMR, and MS data analyses. The isolated compounds were evaluated for their antioxidant activity and inhibitory activity on mushroom tyrosinase. Highly potent inhibitions Were found by compounds 7 (IC50 = 0.38 mM), 8 (IC50 = 0.19 mM), and 12 (IC50 = 0.26 mM) when compared with standard tyrosinase inhibitors kojic acid (IC50 = 0.67 mM) and L-mimosine (IC50 = 0.64 mM). The antioxidative effect of the isolated compounds and the extracts were determined by using, beta-carotene-linoleic acid, DPPH center dot scavenging, ABTS(+center dot) scavenging, superoxide scavenging, and CUPRAC assays. The experimental findings indicated that all the compounds demonstrated activity in all antioxidant activity tests employed except for the compounds 2-6. Compounds 2-6 showed moderate activity only in ABTS(+center dot) scavenging assay. The new compound 1 exhibited better activity than standard alpha-tocopherol in DPPH center dot scavenging, and ABTS(+center dot) scavenging assays. The results show that T. nigrescens can be regarded as a potential source of antioxidant compounds and tyrosinase inhibitors of significance in both the pharmaceutical and food industries.
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TBAG 108T779]
dc.description.sponsorshipWe thank TUBITAK (The Scientific and Technological Research Council of Turkey) for financial support of the project (TBAG 108T779).
dc.identifier.doi10.1021/jf403669k
dc.identifier.endpage12603
dc.identifier.issn0021-8561
dc.identifier.issn1520-5118
dc.identifier.issue51en_US
dc.identifier.pmid24328319
dc.identifier.scopus2-s2.0-84891439638
dc.identifier.scopusqualityQ1
dc.identifier.startpage12598
dc.identifier.urihttps://doi.org/10.1021/jf403669k
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7145
dc.identifier.volume61
dc.identifier.wosWOS:000329137600016
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞabudak, Temine
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Agricultural and Food Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFabaceae
dc.subjectT. nigrescens subsp petrisavi
dc.subjectflavonoids
dc.subjectphenolic compounds
dc.subjecttyrosinase inhibitory activity
dc.subjectantioxidant activity
dc.subjectExtracts
dc.titleAntioxidant and Tyrosinase Inhibitory Activities of Flavonoids from Trifolium nigrescens Subsp petrisavi
dc.typeArticle

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