Lateral flow assays: Principles, designs and labels

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dc.authorscopusid56465916100
dc.authorscopusid6506764918
dc.authorwosidSezgintürk, Mustafa Kemal/AAY-1439-2021
dc.contributor.authorBahadır, Elif Burcu
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.date.accessioned2022-05-11T14:12:19Z
dc.date.available2022-05-11T14:12:19Z
dc.date.issued2016
dc.departmentRektörlüğe Bağlı Bölümler, Rektörlük, Bilimsel ve Teknolojik Araştırmalar Uygulama ve Araştırma Merkezi
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractLateral flow assays (LFAs) have attracted interest due to their friendly user formats, short assay times, little interferences, low costs, and being easy by operated by non-specialized personnel. This technique is based on biochemical interaction of antigen-antibody or probe DNA-target DNA hybridization. A lateral flow assay (LFA) is composed of four parts: a sample pad, which is the area on which sample is dropped; conjugate pad, on which labeled tags combined with biorecognition elements; reaction membrane containing test line and control line for target DNA-probe DNA hybridization or antigen-antibody interaction; and absorbent pad, which reserves waste. For the construction of LFAs gold nanoparticles, colored latex beads, carbon nanoparticles, quantum dots, and enzymes are used as a label for increasing the sensitivity. In this work, the principle of LFAs, biorecognition elements, analytical performances, limits of detection (LODs), linear ranges of developed LFAs in different fields are summarized. Future perspectives in this area are also discussed. (C) 2016 Elsevier B.V. All rights reserved.
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113 Z 678]
dc.description.sponsorshipWe are thankful for the support from TUBITAK (The Scientific and Technological Research Council of Turkey, Project number: 113 Z 678).
dc.identifier.doi10.1016/j.trac.2016.06.006
dc.identifier.endpage306
dc.identifier.issn0165-9936
dc.identifier.issn1879-3142
dc.identifier.scopus2-s2.0-84976350792
dc.identifier.scopusqualityQ1
dc.identifier.startpage286
dc.identifier.urihttps://doi.org/10.1016/j.trac.2016.06.006
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5502
dc.identifier.volume82
dc.identifier.wosWOS:000389009400024
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBahadır, Elif Burcu
dc.institutionauthorSezgintürk, Mustafa Kemal
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofTrac-Trends in Analytical Chemistry
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLateral flow assays
dc.subjectLateral flow devices
dc.subjectImmunochromatographic assays
dc.subjectBiosensors
dc.subjectImmunoassays
dc.subjectImmunochromatographic Strip Test
dc.subjectLinked-Immunosorbent-Assay
dc.subjectOn-Site Detection
dc.subjectBacillus-Anthracis Spores
dc.subjectMulticolor Quantum Dots
dc.subjectEscherichia-Coli O157h7
dc.subjectGold Immunoassay Strip
dc.subjectNucleic-Acid Biosensor
dc.subjectC-Reactive Protein
dc.subjectRapid Detection
dc.titleLateral flow assays: Principles, designs and labels
dc.typeReview Article

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