Intracerebroventricular injection of histamine induces the hypothalamic-pituitary-gonadal axis activation in male rats

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dc.authorid0000-0002-5600-8162
dc.authorid0000-0002-7678-3289
dc.authorscopusid57060367600
dc.authorscopusid56529426800
dc.authorscopusid55356919300
dc.authorscopusid56780223500
dc.authorscopusid57194022849
dc.authorscopusid31967936400
dc.authorscopusid56099810300
dc.authorwosidGuvenc-Bayram, Gokcen/AAR-6815-2021
dc.authorwosidUstuner, Burcu/AAG-7238-2021
dc.authorwosidGokce, Elif/ABA-6294-2020
dc.authorwosidYALCIN, Murat/AAG-6956-2021
dc.authorwosidNiaz, Nasir/AAC-4975-2022
dc.contributor.authorNiaz, Nasir
dc.contributor.authorGüvenç, Gökçen
dc.contributor.authorAltınbaş, Burçin
dc.contributor.authorToker, Mehmed Berk
dc.contributor.authorAydın, Begüm
dc.contributor.authorUdum Küçükşen, Duygu
dc.contributor.authorYalçın, Murat
dc.contributor.authorGökçe, Elif
dc.date.accessioned2022-05-11T14:42:15Z
dc.date.available2022-05-11T14:42:15Z
dc.date.issued2018
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Bilimler Bölümü, Dölerme ve Suni Tohumlama Ana Bilim Dalı
dc.description.abstractBrain histamine holds a key position in the regulation of behavioral states, biological rhythms, body weight, energy metabolism, thermoregulation, fluid balance, stress and reproduction in female animals. However, it is not clear whether central histamine exerts any effect on hypothalamic-pituitary-testicular in male rats and if so, the involvement of type of central histamine receptors. The current study was designed to determine the effect of centrally administrated histamine on plasma gonadotropin hormone-releasing hormone (GnRH), luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone level, and sperm parameters, and to show the mediation of the central histaminergic H1, H2 and H3/H4 receptors on histamine-evoked hormonal and sperm parameters' effects. Studies were performed in male Sprague-Dawley rats. A total of 50 or 100 nmol doses of histamine were injected intracerebroventricularly (icy). 100 nmol dose of histamine significantly caused increases in plasma GnRH, LH, FSH and testosterone levels of animals, but not 50 nmol dose of histamine. Moreover, central pretreatment with chlorpheniramine, histaminergic H1 receptor antagonist (100 nmol), ranitidine and histaminergic H2 receptor antagonist (100 nmol) completely prevented histamine evoked increase in plasma GnRH, LH, FSH and testosterone levels, while thioperamide, histaminergic H3/H4 receptor antagonist (100 nmol) pretreatment failed to reverse sex hormones responses to histamine. Both central histamine treatment alone and central histamine treatment after central histaminergic receptors antagonists' pretreatments did not alter any sperm parameters in rats. In conclusion, our findings show that centrally administered histamine increases plasma GnRH, LH, FSH and testosterone levels of conscious male rats without change any sperm parameters. Moreover, according to our findings, central histaminergic H1, and H2 receptors mediate these histamine-induced effects.
dc.description.sponsorshipCommission of Scientific Research Projects of Uludag UniversityUludag University [OUAP(V)2015/26]
dc.description.sponsorshipThis study was supported by Commission of Scientific Research Projects of Uludag University (OUAP(V)2015/26).
dc.identifier.doi10.1016/j.brainres.2018.08.020
dc.identifier.endpage157
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid30130495
dc.identifier.scopus2-s2.0-85052524375
dc.identifier.scopusqualityQ2
dc.identifier.startpage150
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2018.08.020
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9302
dc.identifier.volume1699
dc.identifier.wosWOS:000449126200016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGökçe, Elif
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofBrain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHistamine
dc.subjectCentral histaminergic receptors
dc.subjectHypothalamic-pituitary-gonadal axis
dc.subjectSperm parameters
dc.subjectIntracerebroventricular
dc.subjectCritical Hemorrhagic Hypotension
dc.subjectFollicle-Stimulating-Hormone
dc.subjectLuteinizing-Hormone
dc.subjectGonadotropin-Secretion
dc.subjectReceptor Subtypes
dc.subjectBeta-Endorphin
dc.subjectSperm Quality
dc.subjectLeydig-Cell
dc.subjectDanish Men
dc.subjectTestosterone
dc.titleIntracerebroventricular injection of histamine induces the hypothalamic-pituitary-gonadal axis activation in male rats
dc.typeArticle

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