Expression of cadherins and some connective tissue components in cow uterus and placenta during pregnancy

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dc.authorscopusid56521500300
dc.authorscopusid6602085918
dc.authorscopusid35114425000
dc.authorscopusid35301900800
dc.authorscopusid9842574500
dc.authorscopusid6602579282
dc.authorscopusid36650778800
dc.authorwosidErdoğan, Serkan/F-5923-2011
dc.contributor.authorSağsöz, Hakan
dc.contributor.authorLiman, Narin
dc.contributor.authorAkbalık, M. Erdem
dc.contributor.authorAlan, Emel
dc.contributor.authorSaruhan, Berna Güney
dc.contributor.authorKetani, M. Aydin
dc.contributor.authorErdoğan, Serkan
dc.date.accessioned2023-04-20T08:01:16Z
dc.date.available2023-04-20T08:01:16Z
dc.date.issued2022
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Anatomi Ana Bilim Dalı
dc.description.abstractThe implantation and placental development processes are regulated with cell adhesion molecules and remod-eling of the maternal endometrium's extracellular matrices (ECM) and fetal chorion. This study aimed to investigate the distribution and localization of some classical cadherins (E-, N-, and P-cadherins) and extracel-lular matrix components collagen type 5 alpha 1, fibronectin, and laminin in the cow placentomes during pregnancy using immunohistochemical and Western blotting analyses. The study results confirmed the expression of E- and P-cadherins, collagen type V alpha 1 (COLV alpha 1), fibronectin, and laminin in the cow placentomes, but not N-cadherin. Throughout the pregnancy, E-and P-cadherins, COLV alpha 1, and laminin were localized in the luminal and glan-dular epithelium of the inter-caruncular endometrium, caruncular epithelium, and the uninucleate (UNCs) and binucleate trophoblast giant cells (BNCs/TGCs). E- cadherin immunoreactivity in the first pregnancy period was strong in the UNCs while moderate in the BNCs/TGCs. However, it was weak in both trophoblast in the second and third pregnancy periods. In the fetal trophoblasts, P-cadherin and laminin immunostainings were more intense in the BNCs/TGCs than UNCs. The fetal and maternal stromal cells were also positive for P-cadherin, COLV alpha 1, fibronectin, and laminin. The immunostaining intensity of COLV alpha 1 and fibronectin in the stromal extracellular matrix of the placentomes decreased as the pregnancy progressed. The endothelia of fetal and maternal vessels were positive for all proteins. The presence and distinct localization of cadherins and ECM proteins in the cow placentome components support the role of these molecules in regulating placental cell growth, migration, and matrix production during pregnancy.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK ARDEB 1002, 116O797]
dc.description.sponsorshipFunding This work was supported by the the Scientific and Technological Research Council of Turkey (TUBITAK ARDEB 1002 Grant No. 116O797) .
dc.identifier.doi10.1016/j.rvsc.2022.07.006
dc.identifier.endpage79
dc.identifier.issn0034-5288
dc.identifier.issn1532-2661
dc.identifier.pmid35870371
dc.identifier.scopus2-s2.0-85134826246
dc.identifier.scopusqualityQ1
dc.identifier.startpage64
dc.identifier.urihttps://doi.org/10.1016/j.rvsc.2022.07.006
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10837
dc.identifier.volume151
dc.identifier.wosWOS:000843032800006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdoğan, Serkan
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofResearch In Veterinary Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBovine
dc.subjectCollagen
dc.subjectLaminin
dc.subjectN-Cadherin
dc.subjectPlacenta
dc.subjectUterus
dc.subjectCollagen-Type-I
dc.subjectExtracellular-Matrix
dc.subjectAdhesion Molecules
dc.subjectBeta-Catenin
dc.subjectV Collagen
dc.subjectCell-Differentiation
dc.subjectIntegrin Receptors
dc.subjectHuman Trophoblast
dc.subjectBovine Placenta
dc.subjectFibronectin
dc.titleExpression of cadherins and some connective tissue components in cow uterus and placenta during pregnancy
dc.typeArticle

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