In vitro effects of amiodarone on coronary artery bypass grafts

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dc.authorid0000-0002-4763-986X
dc.authorscopusid10142081100
dc.authorscopusid7004591561
dc.authorscopusid7003875728
dc.authorscopusid10139012600
dc.authorscopusid6603653874
dc.authorscopusid55318380700
dc.authorscopusid56606984400
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidEcevit, Ata Niyazi/Z-1436-2019
dc.contributor.authorKaraca, Okay Güven
dc.contributor.authorEge, Turan
dc.contributor.authorCanbaz, Suat
dc.contributor.authorGür, Özcan
dc.contributor.authorKaradağ, Çetin Hakan
dc.contributor.authorEcevit, Ata Niyazi
dc.contributor.authorKalender, Mehmet
dc.date.accessioned2022-05-11T14:35:59Z
dc.date.available2022-05-11T14:35:59Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractBackground: This study aims to investigate the effects of amiodarone on the most commonly used grafts, internal thoracic artery (ITA), saphenous vein (SV), and radial artery (RA) in organ bath. Methods: Twenty patients (16 males, 4 females; mean ages 58.4 +/- 9.9 years; range 38 to 80 years) who underwent isolated coronary artery bypass graft (CABG) surgery between May 2008 and October 2008 were included in this study. Internal thoracic artery, saphenous vein, and radial artery grafts were harvested. Specimens were taken to laboratory in +4 degrees C Krebs solution. Specimens were suspended in 10 ml organ bath containing Krebs solution. Results: Amiodarone caused relaxation in all grafts (ITA, RA, SV) between 10(-9)-10(-3,5) M concentration in a dose dependent manner (p<0.01). Maximum relaxation rates (mean) induced by amiodarone were 78.9%, 74.9% and 66.5% for ITA, RA and SV, respectively. Conclusion: Although we did not evaluate the endothelium-independent relaxation response in this study, higher rates of relaxation response were observed with ITA grafts comparing to other grafts, and these results were compatible with literature. According to the results of this study, amiodarone-class III antiarrhythmic agent- caused vasodilation in all three grafts in vitro. Vasodilator effect of amiodarone on grafts may help to increase patency rates.
dc.identifier.doi10.5606/tgkdc.dergisi.2015.9871
dc.identifier.endpage18
dc.identifier.issn1301-5680
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84921734347
dc.identifier.scopusqualityQ3
dc.identifier.startpage14
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2015.9871
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8325
dc.identifier.volume23
dc.identifier.wosWOS:000348962500003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGür, Özcan
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayincilik
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmiodarone
dc.subjectinternal thoracic artery
dc.subjectorgan bath
dc.subjectradial artery
dc.subjectsaphenous vein
dc.subjectAtrial-Fibrillation
dc.subjectCardiothoracic Surgery
dc.subjectHistorical Development
dc.subjectPharmacology
dc.subjectRelaxation
dc.subjectGuidelines
dc.titleIn vitro effects of amiodarone on coronary artery bypass grafts
dc.typeArticle

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