Copy number increase of oncoprotein CIP2A is associated with poor patient survival in human head and neck squamous cell carcinoma

Basit Öğe Kaydı
dc.authorid0000-0002-3015-0929
dc.authorid0000-0001-7478-3018
dc.authorid0000-0001-5385-7065
dc.authorid0000-0001-6672-6662
dc.authorid0000-0002-5004-0364
dc.authorid0000-0001-7051-7855
dc.authorscopusid56919709700
dc.authorscopusid9242258800
dc.authorscopusid7801581235
dc.authorscopusid7004296768
dc.authorscopusid7006392459
dc.authorscopusid6701723954
dc.authorscopusid6602959003
dc.authorwosidBilgen, Turker/N-6376-2018
dc.authorwosidWestermarck, Jukka/AAL-6464-2020
dc.authorwosidVentela, Sami/I-7253-2018
dc.contributor.authorRoutila, Johannes
dc.contributor.authorBilgen, Türker
dc.contributor.authorSaramaki, Outi
dc.contributor.authorGrenman, Reidar
dc.contributor.authorVisakorpi, Tapio
dc.contributor.authorWestermarck, Jukka
dc.contributor.authorVentela, Sami
dc.date.accessioned2022-05-11T14:48:07Z
dc.date.available2022-05-11T14:48:07Z
dc.date.issued2016
dc.departmentRektörlüğe Bağlı Bölümler, Rektörlük, Bilimsel ve Teknolojik Araştırmalar Uygulama ve Araştırma Merkezi
dc.description.abstractBackgroundCIP2A, an inhibitor of PP2A tumour suppressor function, is a widely overexpressed biomarker of aggressive disease and poor therapy response in multiple human cancer types. MethodsCIP2A and DPPA4 copy number alterations and expression were analysed by fluorescence in situ hybridisation (FISH) and immunohistochemistry (IHC) in different cell lines and a tissue microarray of 52 HNSCC patients. Results were correlated with patient survival and other clinicopathological data. ResultsCIP2A and DPPA4 copy number increase occurred at a relatively high frequency in human HNSCC patient samples. CIP2A but not DPPA4 FISH status was significantly associated with patient survival. CIP2A detection by combining IHC with FISH yielded superior resolution in the prognostication of HNSCC. ConclusionsCIP2A copy number increase is associated with poor patient survival in human HNSCC. We suggest that the reliability and prognostic value of CIP2A detection can be improved by performing FISH analysis to CIP2A IHC positive tumours.
dc.description.sponsorshipFinnish Cancer Associations; Foundation of Finnish Cancer Institute
dc.description.sponsorshipWe thank Dr. Ilpo Kinnunen for his kind assistance in preparing this manuscript. This work was supported by funding from Finnish Cancer Associations and from Foundation of Finnish Cancer Institute.
dc.identifier.doi10.1111/jop.12372
dc.identifier.endpage337
dc.identifier.issn0904-2512
dc.identifier.issn1600-0714
dc.identifier.issue5en_US
dc.identifier.pmid26436875
dc.identifier.scopus2-s2.0-84946236611
dc.identifier.scopusqualityQ2
dc.identifier.startpage329
dc.identifier.urihttps://doi.org/10.1111/jop.12372
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10603
dc.identifier.volume45
dc.identifier.wosWOS:000374137600002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBilgen, Türker
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCIP2A
dc.subjectDPPA4
dc.subjecthead and neck
dc.subjectin situ hybridisation
dc.subjectprotein phosphatase 2a
dc.subjectsquamous cell carcinoma
dc.subjectComparative Genomic Hybridization
dc.subjectPrognostic Indicator
dc.subjectCancer Cells
dc.subjectAmplification
dc.subjectProgression
dc.subjectStage
dc.subjectGene
dc.subjectOverexpression
dc.subjectExpression
dc.subjectPp2a
dc.titleCopy number increase of oncoprotein CIP2A is associated with poor patient survival in human head and neck squamous cell carcinoma
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
10603.pdf
Boyut:
756.61 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Bilimsel ve Teknolojik Araştırmalar Uygulama ve Araştırma Merkezi Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu