Copy number increase of oncoprotein CIP2A is associated with poor patient survival in human head and neck squamous cell carcinoma
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
BackgroundCIP2A, an inhibitor of PP2A tumour suppressor function, is a widely overexpressed biomarker of aggressive disease and poor therapy response in multiple human cancer types. MethodsCIP2A and DPPA4 copy number alterations and expression were analysed by fluorescence in situ hybridisation (FISH) and immunohistochemistry (IHC) in different cell lines and a tissue microarray of 52 HNSCC patients. Results were correlated with patient survival and other clinicopathological data. ResultsCIP2A and DPPA4 copy number increase occurred at a relatively high frequency in human HNSCC patient samples. CIP2A but not DPPA4 FISH status was significantly associated with patient survival. CIP2A detection by combining IHC with FISH yielded superior resolution in the prognostication of HNSCC. ConclusionsCIP2A copy number increase is associated with poor patient survival in human HNSCC. We suggest that the reliability and prognostic value of CIP2A detection can be improved by performing FISH analysis to CIP2A IHC positive tumours.
Açıklama
Anahtar Kelimeler
CIP2A, DPPA4, head and neck, in situ hybridisation, protein phosphatase 2a, squamous cell carcinoma, Comparative Genomic Hybridization, Prognostic Indicator, Cancer Cells, Amplification, Progression, Stage, Gene, Overexpression, Expression, Pp2a
Kaynak
Journal of Oral Pathology & Medicine
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
45
Sayı
5
