Increased Circulatory Extrarenal 1 alpha,25-Dihydroxyvitamin D3 in Bilaterally Nephrectomized Rats

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dc.authorid0000-0001-7354-0655
dc.authorid0000-0002-5184-6087
dc.authorscopusid6602159436
dc.authorscopusid6506500938
dc.authorscopusid24778581400
dc.authorscopusid52863212500
dc.authorscopusid7003605484
dc.authorscopusid57219317836
dc.authorwosidÖzöner, Özgür/AAD-3691-2021
dc.authorwosidDABAK, MURAT/W-4245-2018
dc.contributor.authorDabak, Murat
dc.contributor.authorDabak, Durrin O.
dc.contributor.authorKuloğlu, Tuncay
dc.contributor.authorBaydar, Ersoy
dc.contributor.authorBulut, Hakan
dc.contributor.authorÖzöner, Özgür
dc.date.accessioned2022-05-11T14:42:22Z
dc.date.available2022-05-11T14:42:22Z
dc.date.issued2020
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Viroloji Ana Bilim Dalı
dc.description.abstractBackground: Extrarenal 1 alpha,25-dihydroxyvitamin D-3 (1,25-D) locally produced by immune cells plays crucial roles in the regulation of the immune system. However, in vivo status of extrarenal 1,25-D and 25-hydroxyvitamin D (25-D) in acute inflammatory conditions are unknown. Objective: The aim of this study was to determine the extrarenal 1,25-D level in circulation in bilaterally nephrectomized rats, induced by low-dose lipopolysaccharide (LPS). Methods: Renal 1,25-D synthesis was terminated through bilateral nephrectomy in rats. The rats received intraperitoneal LPS (50 mu g/kg BW) three times and the experiment was ended 24 hours after nephrectomy. Serum 1,25-D, 25-D, calcium, phosphorus, intact parathyroid hormone, and calcitonin levels were measured and immunohistochemistry was applied to detect the sources of extrarenal 1,25-D synthesis. Results: Circulatory 1,25-D concentration remarkably increased in both LPS-treated and non-treated bilaterally nephrectomized rats. Elevated circulatory 1,25-D did not have hypercalcemic endocrinal effects. The increased 1,25-D level also resulted in a concurrent rapid and dramatic depletion of circulatory 25-D. Conclusion: Extrarenal 1,25-D could enter into the systemic circulation and, therefore, might have systemic effects besides its autocrine and paracrine functions.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [2140681]
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) (Project Number: 2140681).
dc.identifier.doi10.2174/1871530320666200530222426
dc.identifier.endpage1530
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.issue9en_US
dc.identifier.pmid32473004
dc.identifier.scopus2-s2.0-85092184002
dc.identifier.scopusqualityQ3
dc.identifier.startpage1523
dc.identifier.urihttps://doi.org/10.2174/1871530320666200530222426
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9349
dc.identifier.volume20
dc.identifier.wosWOS:000587329600017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBulut, Hakan
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targets
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject1 alpha,25-dihydroxyvitamin D-3
dc.subject25-hydroxyvitamin D
dc.subjectinflammation
dc.subjectextrarenal
dc.subjectanephric
dc.subjectrat
dc.subjectCultured Alveolar Macrophages
dc.subject1,25-Dihydroxyvitamin-D3 Production
dc.subjectSkeletal Resistance
dc.subjectParathyroid-Hormone
dc.subjectVitamin-D3
dc.subjectExpression
dc.subjectReceptors
dc.subjectPharmacokinetics
dc.subjectIdentification
dc.subjectMetabolites
dc.titleIncreased Circulatory Extrarenal 1 alpha,25-Dihydroxyvitamin D3 in Bilaterally Nephrectomized Rats
dc.typeArticle

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