The comparative effects of esmolol and amiodarone on isolated coronary artery bypass grafts

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dc.authorscopusid55317577700
dc.authorscopusid10139012600
dc.authorscopusid14008084500
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorGür, Özcan
dc.contributor.authorGürkan, Selami
dc.date.accessioned2022-05-11T14:12:28Z
dc.date.available2022-05-11T14:12:28Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractBackground/aim: Esmolol and amiodarone are two most commonly used antiarrhythmic drugs in coronary artery bypass grafting (CABG) surgery. Nevertheless, blockade of beta-2 receptors by increasing doses raise concerns about possible vasospasms. We studied the vasoactive effects of amiodarone and esmolol on left internal mammary artery (LIMA), radial artery (RA), and saphenous vein (SV) grafts. Materials and methods: After determining the presence of functional smooth muscle and endothelial layers, the responses of submaximally preconstricted graft samples were recorded in a tissue bath system. A total of 96 graft samples from 40 patients were used: 16 LIMA, 16 RA, and 16 SV grafts for each drug. Esmolol and amiodarone were added to reservoirs separately, starting from a concentration of 10-8 M until a concentration of 10-4 M. Results: Although both drugs caused vasodilatation, amiodarone exhibited a more potent vasodilatory effect than esmolol (P < 0.0001 for LIMA, P = 0.0128 for RA, and P < 0.0001 for SV). The vasodilatation rates with esmolol were 48.99 +/- 1. 2.28% in LIMA, 49.77 +/- 3.03% in RA, and 41.90 +/- 4.05% in SV grafts and with amiodarone they were 71.65 +/- 5.18% in LIMA, 58.61 +/- 5.87% in RA, and 65.07 +/- 4.09% in SV grafts. Conclusion: This in vitro study revealed that even increasing doses of both drugs induce vasodilatation of CABG grafts, with amiodarone having a more potent vasodilatory effect than esmolol.
dc.identifier.doi10.3906/sag-1802-124
dc.identifier.endpage1072
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.pmid30384577
dc.identifier.scopus2-s2.0-85055915804
dc.identifier.scopusqualityQ3
dc.identifier.startpage1068
dc.identifier.urihttps://doi.org/10.3906/sag-1802-124
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5569
dc.identifier.volume48
dc.identifier.wosWOS:000452889200026
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorGür, Özcan
dc.institutionauthorGürkan, Selami
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAmiodarone
dc.subjectesmolol
dc.subjectcoronary artery bypass grafts
dc.subjecttissue bath system
dc.subjectAtrial-Fibrillation
dc.subjectVasodilation
dc.subjectSurgery
dc.subjectDrug
dc.titleThe comparative effects of esmolol and amiodarone on isolated coronary artery bypass grafts
dc.typeArticle

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