Evaluation of the anesthetic effects of xylazine-ketamine, xylazine-tiletamine-zolazepam and tiletamine-zolazepam using clinical and laboratory parameters in rabbits

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dc.authorid0000-0001-5805-0340
dc.authorid0000-0001-9443-3867
dc.authorscopusid36842696600
dc.authorscopusid12243148200
dc.authorscopusid57212930792
dc.authorscopusid6701549536
dc.authorscopusid35618550600
dc.authorwosidAltug, Nuri/E-3427-2018
dc.authorwosidYüksek, Nazmi/B-4342-2017
dc.authorwosidKARASU, Abdullah/AAE-8884-2020
dc.authorwosidAltug, Nuri/AAJ-3790-2020
dc.contributor.authorKarasu, Abdullah
dc.contributor.authorAltuğ, Nuri
dc.contributor.authorAslan, Logman
dc.contributor.authorBakir, Bahtiyar
dc.contributor.authorYüksek, Nazmi
dc.date.accessioned2022-05-11T14:42:17Z
dc.date.available2022-05-11T14:42:17Z
dc.date.issued2018
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Bilimler Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractThe aim of this study was to evaluate the anesthetic effects of xylazine-ketamine (XK), xylazine-tiletamine-zolazepam (XTZ) and tiletamine-zolazepam (TZ) using hematological and biochemical parameters in rabbits. A total of 18 rabbits were divided into three equal treatment groups (n = 6). The rabbits in the XK, XTZ, and TZ groups were administered xylazine (5 mg/kg) and ketamine (50 mg/kg), xylazine (5 mg/kg) and TZ (15 mg/kg), and TZ (15 mg/kg), respectively, via the intramuscular route. Following the injection, their reflexes were tested every 5 minutes. Heart rate, respiratory rate, and body temperature were determined before the injection (0 min) and at 5, 15, 30, 45, 60, 75, 90, and 120 min after injecting the anesthetic combinations. Furthermore, hematological and biochemical (alanine transaminase [ALT], aspartate transaminase [AST], alkaline phosphatase [ALP], bilirubin, blood urea nitrogen [BUN], and urea) analyses were also performed before, during, and after anesthesia administration. The duration of anesthesia and loss of reflexes were significantly longer in the XTZ group than in the other groups. However, in the TZ group, reflexes were remained. Respiratory rate and body temperature decreased in all the groups. Moreover, heart rate reduced only in the XK and XTZ groups, and the hematological parameters of all groups were comparable. Serum AST and ALP levels increased in the XTZ group compared to that in the XK and TZ groups, respectively. However, these increases were within the reference limits. The post-anesthesia serum BUN and urea levels significantly increased in the XTZ group (p < 0.05) compared to that in the other groups. Thus, although the XTZ combination provided satisfactory anesthetic effect in rabbits, it may be nephrotoxic. Therefore, its use for anesthesia induction in invasive renal procedures and experimental nephrotoxicity studies is not advisable.
dc.identifier.doi10.21521/mw.6119
dc.identifier.endpage652
dc.identifier.issn0025-8628
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85056841301
dc.identifier.scopusqualityQ3
dc.identifier.startpage646
dc.identifier.urihttps://doi.org/10.21521/mw.6119
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9317
dc.identifier.volume74
dc.identifier.wosWOS:000445876900006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAltuğ, Nuri
dc.language.isoen
dc.publisherPolish Soc Veterinary Sciences Editorial Office
dc.relation.ispartofMedycyna Weterynaryjna-Veterinary Medicine-Science and Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectxylazine
dc.subjectketamine
dc.subjecttiletamine-zolazepam
dc.subjectanesthesia
dc.subjecthematology
dc.subjectbiochemistry
dc.subjectrabbit
dc.subjectZealand White-Rabbits
dc.subjectCombinations
dc.subjectMidazolam
dc.subjectTelazol
dc.titleEvaluation of the anesthetic effects of xylazine-ketamine, xylazine-tiletamine-zolazepam and tiletamine-zolazepam using clinical and laboratory parameters in rabbits
dc.typeArticle

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