Curcumin-meropenem synergy in carbapenem resistant klebsiella pneumoniae curcumin-meropenem synergy

Basit Öğe Kaydı
dc.authorscopusid6602366586
dc.authorscopusid16550520100
dc.authorscopusid24483063300
dc.authorscopusid57224919148
dc.contributor.authorGülen, Dumrul
dc.contributor.authorŞafak, Birol
dc.contributor.authorErdal, Berna
dc.contributor.authorGünaydın, Burak
dc.date.accessioned2022-05-11T14:05:12Z
dc.date.available2022-05-11T14:05:12Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractBackground and Objectives: The frequency of multiple resistant bacterial infections, including carbapenems, is increasing worldwide. As the decrease in treatment options causes difficulties in treatment, interest in new antimicrobials is increasing. One of the promising natural ingredients is curcumin. It is known to be effective in bacteria such as Pseudomonas aerugi-nosa, Escherichia coli, Burkholderia pseudomallei through efflux pump inhibition, toxin inhibition and enzymes. However, because its bioavailability is poor, it seffectiveness occurs in combination with antibiotics. In the study, the interaction of meropenem and curcumin in carbapenemase producing strains of Klebsiella pneumoniae was tested. Materials and Methods: Thirty-nine Klebsiella pneumoniae isolates, resistant to meropenem, were used in this study. From those 15 MBL, 6 KPC, 17 OXA-48 and 1 AmpC resistance pattern were detected by combination disk method. Meropenem and Curcumin MIC values were determined by liquid microdilution. Checkerboard liquid microdilution was used to determine the synergy between meropenem and curcumin. Results: Synergistic effects were observed in 4 isolates producing MBL, 3 isolates producing KPC, 4 isolates producing OXA-48, and 1 isolates producing AmpC (totally 12 isolates) according to the calculated FICI. No antagonistic effects were observed in any isolates. Conclusion: Curcumin was thought to be an alternative antimicrobial in combination therapies that would positively con-tribute to the treatment of bacterial infection. The effectiveness of this combination should be confirmed by other in vitro and clinical studies. © 2021 The Authors. Published by Tehran University of Medical Sciences.
dc.identifier.endpage351
dc.identifier.issn2008-3289
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85108635120
dc.identifier.scopusqualityQ3
dc.identifier.startpage345
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4920
dc.identifier.volume13
dc.identifier.wosWOS:000659377500011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGülen, Dumrul
dc.institutionauthorŞafak, Birol
dc.institutionauthorErdal, Berna
dc.institutionauthorGünaydın, Burak
dc.language.isoen
dc.publisherTehran University of Medical Sciences
dc.relation.ispartofIranian Journal of Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnti-bacterial agents
dc.subjectCarbapenemase
dc.subjectCurcumin
dc.subjectDrug synergism
dc.subjectKlebsiella pneumoniae
dc.subjectamoxicillin plus clavulanic acid
dc.subjectampicillin
dc.subjectantibiotic agent
dc.subjectaztreonam
dc.subjectcarbapenem
dc.subjectcarbapenem derivative
dc.subjectcarbapenemase
dc.subjectcefepime
dc.subjectcefotaxime
dc.subjectceftazidime
dc.subjectciprofloxacin
dc.subjectcolistin
dc.subjectcurcumin
dc.subjectertapenem
dc.subjectgentamicin
dc.subjectimipenem
dc.subjectmeropenem
dc.subjectnalidixic acid
dc.subjectquinolone derivative
dc.subjecttigecycline
dc.subjectagar diffusion
dc.subjectantagonistic effect
dc.subjectantibacterial activity
dc.subjectantibiotic resistance
dc.subjectantibiotic sensitivity
dc.subjectantimicrobial activity
dc.subjectArticle
dc.subjectbacterial gene
dc.subjectbacterial growth
dc.subjectbacterial infection
dc.subjectbacterium isolate
dc.subjectbioavailability
dc.subjectbiofilm
dc.subjectbroth dilution
dc.subjectBurkholderia pseudomallei
dc.subjectcarbapenem resistant Klebsiella pneumoniae
dc.subjectcolony forming unit
dc.subjectcontrolled study
dc.subjectdisk diffusion
dc.subjectdrug potentiation
dc.subjectEscherichia coli
dc.subjectin vitro study
dc.subjectKlebsiella pneumoniae
dc.subjectminimum inhibitory concentration
dc.subjectnonhuman
dc.subjectphenotype
dc.subjectPseudomonas aeruginosa
dc.subjectStaphylococcus aureus
dc.subjectStaphylococcus pseudintermedius
dc.subjectsynergistic effect
dc.subjectzone of inhibition
dc.titleCurcumin-meropenem synergy in carbapenem resistant klebsiella pneumoniae curcumin-meropenem synergy
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
4920.pdf
Boyut:
3.21 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu