Curcumin-meropenem synergy in carbapenem resistant klebsiella pneumoniae curcumin-meropenem synergy
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Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tehran University of Medical Sciences
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and Objectives: The frequency of multiple resistant bacterial infections, including carbapenems, is increasing worldwide. As the decrease in treatment options causes difficulties in treatment, interest in new antimicrobials is increasing. One of the promising natural ingredients is curcumin. It is known to be effective in bacteria such as Pseudomonas aerugi-nosa, Escherichia coli, Burkholderia pseudomallei through efflux pump inhibition, toxin inhibition and enzymes. However, because its bioavailability is poor, it seffectiveness occurs in combination with antibiotics. In the study, the interaction of meropenem and curcumin in carbapenemase producing strains of Klebsiella pneumoniae was tested. Materials and Methods: Thirty-nine Klebsiella pneumoniae isolates, resistant to meropenem, were used in this study. From those 15 MBL, 6 KPC, 17 OXA-48 and 1 AmpC resistance pattern were detected by combination disk method. Meropenem and Curcumin MIC values were determined by liquid microdilution. Checkerboard liquid microdilution was used to determine the synergy between meropenem and curcumin. Results: Synergistic effects were observed in 4 isolates producing MBL, 3 isolates producing KPC, 4 isolates producing OXA-48, and 1 isolates producing AmpC (totally 12 isolates) according to the calculated FICI. No antagonistic effects were observed in any isolates. Conclusion: Curcumin was thought to be an alternative antimicrobial in combination therapies that would positively con-tribute to the treatment of bacterial infection. The effectiveness of this combination should be confirmed by other in vitro and clinical studies. © 2021 The Authors. Published by Tehran University of Medical Sciences.
Açıklama
Anahtar Kelimeler
Anti-bacterial agents, Carbapenemase, Curcumin, Drug synergism, Klebsiella pneumoniae, amoxicillin plus clavulanic acid, ampicillin, antibiotic agent, aztreonam, carbapenem, carbapenem derivative, carbapenemase, cefepime, cefotaxime, ceftazidime, ciprofloxacin, colistin, curcumin, ertapenem, gentamicin, imipenem, meropenem, nalidixic acid, quinolone derivative, tigecycline, agar diffusion, antagonistic effect, antibacterial activity, antibiotic resistance, antibiotic sensitivity, antimicrobial activity, Article, bacterial gene, bacterial growth, bacterial infection, bacterium isolate, bioavailability, biofilm, broth dilution, Burkholderia pseudomallei, carbapenem resistant Klebsiella pneumoniae, colony forming unit, controlled study, disk diffusion, drug potentiation, Escherichia coli, in vitro study, Klebsiella pneumoniae, minimum inhibitory concentration, nonhuman, phenotype, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus pseudintermedius, synergistic effect, zone of inhibition
Kaynak
Iranian Journal of Microbiology
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
13
Sayı
3
