YKL-40 is a local marker for inflammation in patients with pseudoexfoliation syndrome

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dc.authorscopusid34869701000
dc.authorscopusid23968920100
dc.authorscopusid55913025800
dc.contributor.authorGönen, Tansu
dc.contributor.authorGüzel, Savaş
dc.contributor.authorKeskinbora, Kadircan Hıdır
dc.date.accessioned2022-05-11T14:04:54Z
dc.date.available2022-05-11T14:04:54Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose: To investigate the YKL-40, as a marker of inflammation, in aqueous humor and serum of cataract patients with and without pseudoexfoliation syndrome (PEX). Methods: Aqueous humor and serum samples were obtained from 44 patients who underwent phacoemulsification surgery. All patients were divided into two groups: PEX (n = 24) and control (n = 20). YKL-40 levels were measured with enzyme-linked immunosorbent assay (ELISA). The differences between the groups were assessed by using Chi-square and independent sample t-tests. The Pearson correlation coefficient was used to evaluate the correlation between variables. Results: There was a significant difference between the mean YKL-40 levels in the aqueous humor of PEX group (112.0 ± 35.8 ng/mL) and control subjects (88.2 ± 30.6 ng/mL) (P = 0.025). However, the difference between the mean YKL-40 levels in the serum of PEX group (53.5 ± 29.1 ng/mL) and control subjects (44.6 ± 30.2 ng/mL) was non-significant (P = 0.326). The correlation between aqueous humor and serum YKL-40 concentrations was significant in both the groups (r = 0.833, P < 0.001; r = 0.840, P < 0.001, respectively). Conclusions: Increased aqueous humor levels of YKL-40 demonstrate that it is local, but not a systemic marker for inflammation in patients with PEX. © 2018, The Royal College of Ophthalmologists.
dc.identifier.doi10.1038/s41433-018-0308-8
dc.identifier.endpage776
dc.identifier.issn0950-222X
dc.identifier.issue5en_US
dc.identifier.pmid30560917
dc.identifier.scopus2-s2.0-85058786152
dc.identifier.scopusqualityQ1
dc.identifier.startpage772
dc.identifier.urihttps://doi.org/10.1038/s41433-018-0308-8
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4832
dc.identifier.volume33
dc.identifier.wosWOS:000467229300013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGonen, Tansu
dc.institutionauthorKeskinbora, Kadircan Hıdır
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.ispartofEye (Basingstoke)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbiological marker
dc.subjectchitinase 3 like protein 1
dc.subjecttropicamide
dc.subjectbiological marker
dc.subjectCHI3L1 protein, human
dc.subjectchitinase 3 like protein 1
dc.subjectgrowth promotor
dc.subjectaged
dc.subjectanterior lens capsule
dc.subjectaqueous humor
dc.subjectArticle
dc.subjectblood sampling
dc.subjectcase control study
dc.subjectcataract
dc.subjectclinical article
dc.subjectcollege
dc.subjectcontrolled study
dc.subjectcorrelation coefficient
dc.subjectenzyme linked immunosorbent assay
dc.subjecteye examination
dc.subjectfemale
dc.subjectgonioscopy
dc.subjecthuman
dc.subjectinflammation
dc.subjectintraocular pressure
dc.subjectlaboratory test
dc.subjectmale
dc.subjectophthalmoscopy
dc.subjectphacoemulsification
dc.subjectprospective study
dc.subjectprotein blood level
dc.subjectpseudoexfoliation
dc.subjectsenile cataract
dc.subjectserum
dc.subjectslit lamp microscopy
dc.subjecttonometry
dc.subjectblood
dc.subjectinflammation
dc.subjectmetabolism
dc.subjectpseudoexfoliation
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAqueous Humor
dc.subjectBiomarkers
dc.subjectCase-Control Studies
dc.subjectCataract
dc.subjectChitinase-3-Like Protein 1
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectExfoliation Syndrome
dc.subjectFemale
dc.subjectGrowth Substances
dc.subjectHumans
dc.subjectInflammation
dc.subjectMale
dc.subjectPhacoemulsification
dc.subjectProspective Studies
dc.titleYKL-40 is a local marker for inflammation in patients with pseudoexfoliation syndrome
dc.typeArticle

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